2003
Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse
Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Staib LH, Soufer R, Charney DS. Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse. Biological Psychiatry 2003, 53: 879-889. PMID: 12742675, DOI: 10.1016/s0006-3223(02)01891-7.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAbuse-related posttraumatic stress disorderMedial prefrontal cortexBrain areasPrefrontal cortexEarly childhood sexual abuseBlood flowChildhood abuse-related posttraumatic stress disorderSexual abuse-related posttraumatic stress disorderStress disorderChildhood sexual abuseCerebral blood flowPositron emission tomographic measurementsSpecific brain areasInferior temporal gyrusInferior parietal cortexMiddle frontal gyrusNeural correlatesTrauma-specific stimuliDeclarative memoryMotor cortexControl subjectsFrontal cortexSymptom provocationAnimal studies
2001
Gender differences in cognitive and neural correlates of remembrance of emotional words.
Bremner J, Soufer R, McCarthy G, Delaney R, Staib L, Duncan J, Charney D. Gender differences in cognitive and neural correlates of remembrance of emotional words. Psychopharmacology Bulletin 2001, 35: 55-78. PMID: 12397879.Peer-Reviewed Original ResearchConceptsEmotional wordsEmotional contentNeural correlatesWord pairsSuperior verbal memorySpecific cognitive functionsBilateral posterior hippocampusSuperior spatial memoryMedial prefrontal cortexGender differencesProcessing of informationNeutral wordsCognitive appraisalVerbal memoryPossible gender differencesHuman cognitionMemory performanceSet of listsGreater activationPosterior hippocampusPrefrontal cortexCognitive functionEmotional dimensionsSpatial memoryEmotional impact
2000
Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder
Bremner J, Innis R, Southwick S, Staib L, Zoghbi S, Charney D. Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder. American Journal Of Psychiatry 2000, 157: 1120-1126. PMID: 10873921, DOI: 10.1176/appi.ajp.157.7.1120.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingPosttraumatic stress disorderBenzodiazepine receptorsReceptor bindingPrefrontal cortexComparison subjectsCase-matched healthy comparison subjectsDistribution volumeStress disorderSymptoms of PTSDBenzodiazepine receptor functionLow distribution volumeHealthy comparison subjectsCombat-related posttraumatic stress disorderMedial prefrontal cortexCentral benzodiazepine receptorsSingle photon emissionStatistical parametric mappingFrontal cortexPTSD patientsPatientsReceptor functionCortexTomography imagingParametric mapping
1999
Neural Correlates of Memories of Childhood Sexual Abuse in Women With and Without Posttraumatic Stress Disorder
Bremner J, Narayan M, Staib L, Southwick S, McGlashan T, Charney D. Neural Correlates of Memories of Childhood Sexual Abuse in Women With and Without Posttraumatic Stress Disorder. American Journal Of Psychiatry 1999, 156: 1787-1795. PMID: 10553744, PMCID: PMC3233772, DOI: 10.1176/ajp.156.11.1787.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderBlood flowVisual association cortexMedial prefrontal cortexChildhood sexual abusePrefrontal cortexMotor cortexAssociation cortexPosterior cingulateStress disorderBrain blood flowChildhood abuseInferior temporal gyrusPositron emission tomographyNeural correlatesSexual abuseSubcallosal gyrusRight hippocampusLong-term effectsFailure of activationAnterior prefrontal cortexBrain areasAnterior cingulateTraumatic remindersEmission tomographyNeural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study
Bremner J, Staib L, Kaloupek D, Southwick S, Soufer R, Charney D. Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study. Biological Psychiatry 1999, 45: 806-816. PMID: 10202567, PMCID: PMC3233761, DOI: 10.1016/s0006-3223(98)00297-2.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderNon-PTSD subjectsBlood flowVietnam combat veteransCerebral blood flow responseStress disorderBlood flow responsePositron emission tomography studySymptoms of patientsCerebral blood flowSubcortical brain areasEmission tomography studiesCombat veteransMedial prefrontal cortexPositron emission tomographyInferior parietal cortexNeural correlatesVisuospatial processingPTSD subjectsPTSD patientsBrain areasLingual gyrusAnterior cingulatePosterior cingulateParietal cortex