2006
IL-10 regulation of lupus in the NZM2410 murine model
Blenman KR, Duan B, Xu Z, Wan S, Atkinson MA, Flotte TR, Croker BP, Morel L. IL-10 regulation of lupus in the NZM2410 murine model. Laboratory Investigation 2006, 86: 1136-1148. PMID: 16924244, DOI: 10.1038/labinvest.3700468.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearB-Lymphocyte SubsetsCD4-Positive T-LymphocytesDisease Models, AnimalFemaleGene Expression RegulationGene Transfer TechniquesGenetic Predisposition to DiseaseGenetic TherapyInterleukin-10KidneyLupus Erythematosus, SystemicLupus NephritisMiceMice, CongenicMice, Inbred C57BLMice, Inbred NZBReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSpecific Pathogen-Free OrganismsSpleenConceptsIL-10T cell activationMurine modelB cellsElevated IL-10IL-10 levelsSubset of CD4Auto-antibody productionB-cell phenotypeMajor effector armMonths of ageIL-10 regulationMuscle gene deliveryClinical nephritisSLE patientsRegulatory cellsProinflammatory responseSystemic autoimmunityRegulatory cytokinesEffector armSLE susceptibility lociT cellsC57BL/6 backgroundMyeloid cellsCongenic model
2004
Aberrant signaling in the TNFα/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse
Blenman KR, Bahjat FR, Moldawer LL, Morel L. Aberrant signaling in the TNFα/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse. Clinical Immunology 2004, 110: 124-133. PMID: 15003809, DOI: 10.1016/j.clim.2003.09.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDApoptosisAspartate AminotransferasesCaspase 3CaspasesCytotoxicity Tests, ImmunologicFemaleGalactosamineIn Situ Nick-End LabelingInterleukin-10Interleukin-6LipopolysaccharidesLiverLupus Erythematosus, SystemicMaleMiceMice, CongenicMice, Inbred C57BLReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type ISignal TransductionTumor Necrosis Factor-alpha
2001
The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
Morel L, Blenman K, Croker B, Wakeland E. The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 1787-1792. PMID: 11172029, PMCID: PMC29335, DOI: 10.1073/pnas.98.4.1787.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody FormationChromatinGenetic Predisposition to DiseaseLupus Erythematosus, SystemicLupus NephritisMiceMice, Inbred C57BLMultigene FamilyConceptsSusceptibility lociComplex trait lociCluster of genesFine-mapping analysisSystemic lupus erythematosus susceptibility lociTrait lociGenomic intervalsEpistatic interactionsModifier lociChromosomal regionsGenetic complexityAdditional lociLociCongenic analysisSusceptibility genesGenesCongenic intervalChromatinCellular characteristicsCell functionMapping analysisMultiple human studiesRelated functionsAutoimmune phenotypeSle1
2000
Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains
Morel L, Croker B, Blenman K, Mohan C, Huang G, Gilkeson G, Wakeland E. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 6670-6675. PMID: 10841565, PMCID: PMC18697, DOI: 10.1073/pnas.97.12.6670.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAutoantibodiesB7-2 AntigenChromosome MappingFemaleLupus Erythematosus, SystemicLupus NephritisLymphocyte ActivationMaleMembrane GlycoproteinsMiceMice, Inbred C57BLConceptsLoss of toleranceSystemic autoimmunityLupus-prone NZM2410 mouseFull disease expressionSevere systemic autoimmunitySystemic lupus erythematosusLupus-prone strainsLupus susceptibility genesFatal glomerulonephritisFatal lupusSevere glomerulonephritisLupus erythematosusKidney failureT cellsMurine strainsC57BL/6 backgroundB cellsAutoimmune phenotypeDisease pathogenesisNZM2410 miceTherapeutic interventionsFatal diseaseDisease expressionCongenic dissectionNuclear antigen
1996
Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain
Morel L, Yu Y, Blenman KR, Caldwell RA, Wakeland EK. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mammalian Genome 1996, 7: 335-339. PMID: 8661718, DOI: 10.1007/s003359900098.Peer-Reviewed Original ResearchConceptsGenomic intervalsSLE susceptibility genesSingle genomic intervalComplex polygenic traitCongenic strainsSLE susceptibility lociGenetic interactionsPositional cloningPolygenic traitGenetic crossesInterval mappingPhenotypic dataGenetic analysisNZM2410 mouse modelNZM2410 strainComponent phenotypesChromosome 17Congenic miceGenesMarker-assisted selection protocolSusceptibility allelesPolygenic modelComplex pathogenic mechanismsSelection protocolPathogenic mechanisms