Immune correlates of talactoferrin alfa in biopsied tumor of relapsed/refractory metastatic non-small cell lung cancer patients
Riess JW, Bhattacharya N, Blenman KR, Neal JW, Hwang G, Pultar P, Salcedo M, Engleman E, Lee PP, Malik R, Wakelee HA. Immune correlates of talactoferrin alfa in biopsied tumor of relapsed/refractory metastatic non-small cell lung cancer patients. Immunopharmacology And Immunotoxicology 2014, 36: 182-186. PMID: 24494587, PMCID: PMC6464638, DOI: 10.3109/08923973.2013.864671.Peer-Reviewed Original ResearchConceptsMetastatic non-small cell lung cancer patientsNon-small cell lung cancer patientsCell lung cancer patientsTalactoferrin alfaLung cancer patientsImmune correlatesCancer patientsQuantitative immunohistochemistryNegative phase III trialsPhase II trial resultsImmune cell parametersTotal immune cellsTreatment tumor biopsiesPhase III trialsPre-treatment biopsiesInfiltration of tumorsDendritic cell maturationImmune cell populationsUnique recombinant formsMetastatic NSCLCIII trialsNSCLC patientsSystemic treatmentTrial closureCytokine release