2022
Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood
Wall I, Boulat V, Shah A, Blenman KRM, Wu Y, Alberts E, Calado DP, Salgado R, Grigoriadis A. Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood. Cancers 2022, 14: 4505. PMID: 36139665, PMCID: PMC9496983, DOI: 10.3390/cancers14184505.Peer-Reviewed Original ResearchBreast cancerPeripheral bloodImmune responseAnti-tumor responseSystemic immune responsesBreast cancer patientsPatient selection parametersEnvironment triadImmune profileLymph nodesImmunological featuresCancer patientsPrimary tumorDisease progressionImmune sitesSurvival rateCancerPatientsTumorsOverall responseBloodFuture studiesTreatmentSignificant overall responseMultiple sites
2020
Comparison of PD-L1 protein expression between primary tumors and metastatic lesions in triple negative breast cancers
Rozenblit M, Huang R, Danziger N, Hegde P, Alexander B, Ramkissoon S, Blenman K, Ross JS, Rimm DL, Pusztai L. Comparison of PD-L1 protein expression between primary tumors and metastatic lesions in triple negative breast cancers. Journal For ImmunoTherapy Of Cancer 2020, 8: e001558. PMID: 33239417, PMCID: PMC7689582, DOI: 10.1136/jitc-2020-001558.Peer-Reviewed Original ResearchConceptsPD-L1 positivity ratePD-L1 positivityPD-L1 expressionDifferent metastatic sitesPrimary tumorMetastatic sitesPositivity rateImmune cellsMetastatic lesionsTumor cellsPD-L1 protein expressionTriple-negative breast cancerMore primary tumorsTriple negative breast cancer tumorsPrimary breast lesionsPrimary outcome measureSoft tissueNegative breast cancerLow positivity rateBreast cancer tumorsBone metastasesFoundation MedicineLymph nodesPD-L1Spearman correlation coefficient
2018
Sentinel lymph node B cells can predict disease-free survival in breast cancer patients
Blenman KRM, He TF, Frankel PH, Ruel NH, Schwartz EJ, Krag DN, Tan LK, Yim JH, Mortimer JE, Yuan Y, Lee PP. Sentinel lymph node B cells can predict disease-free survival in breast cancer patients. Npj Breast Cancer 2018, 4: 28. PMID: 30155518, PMCID: PMC6107630, DOI: 10.1038/s41523-018-0081-7.Peer-Reviewed Original ResearchSentinel lymph nodesTriple-negative breast cancerBreast cancer patientsB cellsLymph nodesCancer patientsImmune cellsBreast cancerNegative triple negative breast cancerTumor-negative patientsTumor-positive nodesDisease-free survivalAdditional prognostic informationTNM staging systemTumor invasion statusPositive nodesNegative patientsSentinel lymphDendritic cellsStaging systemPrognostic informationUnivariate analysisT cellsDiscovery cohortSeparate cohort