2001
The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
Morel L, Blenman K, Croker B, Wakeland E. The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 1787-1792. PMID: 11172029, PMCID: PMC29335, DOI: 10.1073/pnas.98.4.1787.Peer-Reviewed Original ResearchConceptsSusceptibility lociComplex trait lociCluster of genesFine-mapping analysisSystemic lupus erythematosus susceptibility lociTrait lociGenomic intervalsEpistatic interactionsModifier lociChromosomal regionsGenetic complexityAdditional lociLociCongenic analysisSusceptibility genesGenesCongenic intervalChromatinCellular characteristicsCell functionMapping analysisMultiple human studiesRelated functionsAutoimmune phenotypeSle1
1996
Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain
Morel L, Yu Y, Blenman KR, Caldwell RA, Wakeland EK. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mammalian Genome 1996, 7: 335-339. PMID: 8661718, DOI: 10.1007/s003359900098.Peer-Reviewed Original ResearchConceptsGenomic intervalsSLE susceptibility genesSingle genomic intervalComplex polygenic traitCongenic strainsSLE susceptibility lociGenetic interactionsPositional cloningPolygenic traitGenetic crossesInterval mappingPhenotypic dataGenetic analysisNZM2410 mouse modelNZM2410 strainComponent phenotypesChromosome 17Congenic miceGenesMarker-assisted selection protocolSusceptibility allelesPolygenic modelComplex pathogenic mechanismsSelection protocolPathogenic mechanisms