2004
Aberrant signaling in the TNFα/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse
Blenman KR, Bahjat FR, Moldawer LL, Morel L. Aberrant signaling in the TNFα/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse. Clinical Immunology 2004, 110: 124-133. PMID: 15003809, DOI: 10.1016/j.clim.2003.09.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDApoptosisAspartate AminotransferasesCaspase 3CaspasesCytotoxicity Tests, ImmunologicFemaleGalactosamineIn Situ Nick-End LabelingInterleukin-10Interleukin-6LipopolysaccharidesLiverLupus Erythematosus, SystemicMaleMiceMice, CongenicMice, Inbred C57BLReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type ISignal TransductionTumor Necrosis Factor-alpha
1996
Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain
Morel L, Yu Y, Blenman KR, Caldwell RA, Wakeland EK. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mammalian Genome 1996, 7: 335-339. PMID: 8661718, DOI: 10.1007/s003359900098.Peer-Reviewed Original ResearchConceptsGenomic intervalsSLE susceptibility genesSingle genomic intervalComplex polygenic traitCongenic strainsSLE susceptibility lociGenetic interactionsPositional cloningPolygenic traitGenetic crossesInterval mappingPhenotypic dataGenetic analysisNZM2410 mouse modelNZM2410 strainComponent phenotypesChromosome 17Congenic miceGenesMarker-assisted selection protocolSusceptibility allelesPolygenic modelComplex pathogenic mechanismsSelection protocolPathogenic mechanisms