Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain
Morel L, Yu Y, Blenman KR, Caldwell RA, Wakeland EK. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mammalian Genome 1996, 7: 335-339. PMID: 8661718, DOI: 10.1007/s003359900098.Peer-Reviewed Original ResearchConceptsGenomic intervalsSLE susceptibility genesSingle genomic intervalComplex polygenic traitCongenic strainsSLE susceptibility lociGenetic interactionsPositional cloningPolygenic traitGenetic crossesInterval mappingPhenotypic dataGenetic analysisNZM2410 mouse modelNZM2410 strainComponent phenotypesChromosome 17Congenic miceGenesMarker-assisted selection protocolSusceptibility allelesPolygenic modelComplex pathogenic mechanismsSelection protocolPathogenic mechanisms