A High Productivity/Low Maintenance Approach to High-performance Computation for Biomedicine: Four Case Studies
Carriero N, Osier MV, Cheung KH, Miller PL, Gerstein M, Zhao H, Wu B, Rifkin S, Chang J, Zhang H, White K, Williams K, Schultz M. A High Productivity/Low Maintenance Approach to High-performance Computation for Biomedicine: Four Case Studies. Journal Of The American Medical Informatics Association 2004, 12: 90-98. PMID: 15492032, PMCID: PMC543832, DOI: 10.1197/jamia.m1571.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceComputational BiologyComputing MethodologiesMass SpectrometryMicroarray AnalysisPhenotypeSequence AnalysisConceptsHigh performance computationLow-maintenance approachBioinformatics applicationsRepresentative bioinformatics applicationsIntensive bioinformatics applicationsBioinformatics case studyGenome-wide sequence comparisonHPC expertsHPC platformsComplex genetic analysisBioinformatics researchersSignificant speedupMass spectrometry data setsHigh-throughput biotechnologiesSequence comparisonVast amountProteomic dataOrdinal phenotypesSpectrum of techniquesDNA microarraysGenetic analysisGene expressionCase studyIterative refinementMaintenance approach