2004
A High Productivity/Low Maintenance Approach to High-performance Computation for Biomedicine: Four Case Studies
Carriero N, Osier MV, Cheung KH, Miller PL, Gerstein M, Zhao H, Wu B, Rifkin S, Chang J, Zhang H, White K, Williams K, Schultz M. A High Productivity/Low Maintenance Approach to High-performance Computation for Biomedicine: Four Case Studies. Journal Of The American Medical Informatics Association 2004, 12: 90-98. PMID: 15492032, PMCID: PMC543832, DOI: 10.1197/jamia.m1571.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceComputational BiologyComputing MethodologiesMass SpectrometryMicroarray AnalysisPhenotypeSequence AnalysisConceptsHigh performance computationLow-maintenance approachBioinformatics applicationsRepresentative bioinformatics applicationsIntensive bioinformatics applicationsBioinformatics case studyGenome-wide sequence comparisonHPC expertsHPC platformsComplex genetic analysisBioinformatics researchersSignificant speedupMass spectrometry data setsHigh-throughput biotechnologiesSequence comparisonVast amountProteomic dataOrdinal phenotypesSpectrum of techniquesDNA microarraysGenetic analysisGene expressionCase studyIterative refinementMaintenance approach
1998
Identification of Protein-ArginineN-Methyltransferase as 10-Formyltetrahydrofolate Dehydrogenase*
Kim S, Park G, Joo W, Paik W, Cook R, Williams K. Identification of Protein-ArginineN-Methyltransferase as 10-Formyltetrahydrofolate Dehydrogenase*. Journal Of Biological Chemistry 1998, 273: 27374-27382. PMID: 9765265, DOI: 10.1074/jbc.273.42.27374.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBlotting, WesternChromatography, AffinityChromatography, High Pressure LiquidGas Chromatography-Mass SpectrometryLeucovorinLiverMolecular Sequence DataOxidoreductases Acting on CH-NH Group DonorsPeptide MappingProtein-Arginine N-MethyltransferasesRatsRecombinant ProteinsSepharoseSequence Analysis
1997
Enzymatic cleavage and HPLC peptide mapping of proteins
Williams K, Stone K. Enzymatic cleavage and HPLC peptide mapping of proteins. Molecular Biotechnology 1997, 8: 155-167. PMID: 9406186, DOI: 10.1007/bf02752260.Peer-Reviewed Original Research