2018
Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface
Carette X, Platig J, Young D, Helmel M, Young A, Wang Z, Potluri L, Moody C, Zeng J, Prisic S, Paulson J, Muntel J, Madduri A, Velarde J, Mayfield J, Locher C, Wang T, Quackenbush J, Rhee K, Moody D, Steen H, Husson R. Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface. MBio 2018, 9: 10.1128/mbio.02333-17. PMID: 29511081, PMCID: PMC5845002, DOI: 10.1128/mbio.02333-17.Peer-Reviewed Original ResearchConceptsMycobacterial cell envelopeCell envelopePeptidoglycan turnoverProtein abundanceResponse regulator MtrAProtein secretion systemStress responseEnvelope stress responsePhosphorylated cellular proteinsRegulate essential processesDifferentially phosphorylated proteinsSerine/threonine protein kinaseTransport of proteinsLevel of gene expressionAnalysis of phosphoproteinsEssential cell functionsLevel of phosphorylationDNA binding activityDecreased expression of genesCell wall lipidsExpression of genesLipid contentIncreasing multidrug resistanceSecretion systemVirulence determinants
2015
Methylome Analysis in Chickens Immunized with Infectious Laryngotracheitis Vaccine
Carrillo J, He Y, Luo J, Menendez K, Tablante N, Zhao K, Paulson J, Li B, Song J. Methylome Analysis in Chickens Immunized with Infectious Laryngotracheitis Vaccine. PLOS ONE 2015, 10: e0100476. PMID: 26107953, PMCID: PMC4481310, DOI: 10.1371/journal.pone.0100476.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChickensCpG IslandsDNA MethylationEukaryotic Initiation Factor-2Gene Regulatory NetworksGenomeHerpesvirus 1, GallidImmune System DiseasesInflammationRibosomal Protein S6 Kinases, 70-kDaRNA Processing, Post-TranscriptionalSignal TransductionTOR Serine-Threonine KinasesTranscription Initiation SiteVaccinesConceptsTranscription start siteMethyl-CpG binding domain protein-enriched genome sequencingDNA methylationProtein-enriched genome sequencingRNA post-transcriptional modificationsIdentified canonical pathwaysRegulation of eIF4Post-transcriptional modificationsDifferentially expressed genesAxonal guidance signalingGlobal DNA methylationHypermethylated DMRsP70S6K signalingGenome sequenceStart siteMethylome analysisCpG islandsGene networksMethyl-CpGEIF2 signalingCanonical pathwaysK signalingGenesMTOR signalingInfectious laryngotracheitis