2018
Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface
Carette X, Platig J, Young D, Helmel M, Young A, Wang Z, Potluri L, Moody C, Zeng J, Prisic S, Paulson J, Muntel J, Madduri A, Velarde J, Mayfield J, Locher C, Wang T, Quackenbush J, Rhee K, Moody D, Steen H, Husson R. Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface. MBio 2018, 9: 10.1128/mbio.02333-17. PMID: 29511081, PMCID: PMC5845002, DOI: 10.1128/mbio.02333-17.Peer-Reviewed Original ResearchConceptsMycobacterial cell envelopeCell envelopePeptidoglycan turnoverProtein abundanceResponse regulator MtrAProtein secretion systemStress responseEnvelope stress responsePhosphorylated cellular proteinsRegulate essential processesDifferentially phosphorylated proteinsSerine/threonine protein kinaseTransport of proteinsLevel of gene expressionAnalysis of phosphoproteinsEssential cell functionsLevel of phosphorylationDNA binding activityDecreased expression of genesCell wall lipidsExpression of genesLipid contentIncreasing multidrug resistanceSecretion systemVirulence determinants
2016
Dynamic metabolic exchange governs a marine algal-bacterial interaction
Segev E, Wyche T, Kim K, Petersen J, Ellebrandt C, Vlamakis H, Barteneva N, Paulson J, Chai L, Clardy J, Kolter R. Dynamic metabolic exchange governs a marine algal-bacterial interaction. ELife 2016, 5: e17473. PMID: 27855786, PMCID: PMC5148602, DOI: 10.7554/elife.17473.Peer-Reviewed Original ResearchConceptsIndole-3-acetic acidAlgal cellsBacterial production of indole-3-acetic acidProduction of indole-3-acetic acidPhytohormone indole-3-acetic acidProgrammed cell deathPromote algal growthRoseobacter groupAlgal hostOxidative stress responseCoccolithophore physiologyMicro-algaeBacterial productionAlgal deathLaboratory model systemsCell deathAlgalAlgal growthMetabolic exchangeStress responsePopulation dynamicsBacteriaGrowth enhancementModel systemRoseobacter