Multivariable association discovery in population-scale meta-omics studies
Mallick H, Rahnavard A, McIver L, Ma S, Zhang Y, Nguyen L, Tickle T, Weingart G, Ren B, Schwager E, Chatterjee S, Thompson K, Wilkinson J, Subramanian A, Lu Y, Waldron L, Paulson J, Franzosa E, Bravo H, Huttenhower C. Multivariable association discovery in population-scale meta-omics studies. PLOS Computational Biology 2021, 17: e1009442. PMID: 34784344, PMCID: PMC8714082, DOI: 10.1371/journal.pcbi.1009442.Peer-Reviewed Original ResearchConceptsMicrobial community measurementsMeta-omics studiesMicrobial community featuresMulti-omics datasetsControlling false discoveriesLandscape of inflammatory bowel diseaseHuman microbiomeMaAsLinMulti-omicsOmics profilesFalse discoveriesCommunity measuresMicrobiomeEnvironmental conditionsInflammatory bowel diseaseCommunity featuresHealth outcomesAssociation discoveryMultivariate associationsMultiple covariatesEpidemiological studiesLongitudinal designObservational studyStatistical powerZero-inflation