2018
Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry
Park SJH, Pottackal J, Ke JB, Jun NY, Rahmani P, Kim IJ, Singer JH, Demb JB. Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry. Journal Of Neuroscience 2018, 38: 3753-3766. PMID: 29572434, PMCID: PMC5895998, DOI: 10.1523/jneurosci.2518-17.2018.Peer-Reviewed Original ResearchConceptsAlpha ganglion cellsGanglion cell typesAmacrine cellsGanglion cellsCRH cellsAlpha cellsGABAergic synapsesInhibitory interneuronsExcitation/inhibition balanceCorticotropin-releasing hormoneCre transgenic miceFire action potentialsTonic excitatory driveCell typesBalance of excitationGABA releaseExcitatory circuitsRetinal circuitryExcitatory driveInhibition balanceInhibitory inputsMammalian retinaMouse retinaAction potentialsOptogenetic analyses
2016
Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus
Byun H, Kwon S, Ahn HJ, Liu H, Forrest D, Demb JB, Kim IJ. Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus. The Journal Of Comparative Neurology 2016, 524: 2300-2321. PMID: 26713509, PMCID: PMC4892959, DOI: 10.1002/cne.23952.Peer-Reviewed Original ResearchConceptsSpecific cell typesCell typesMolecular markersEts variant gene 1Distinct expression patternsSuperior colliculusMouse SSCsTranscription factorsCadherin-7Retinoid-related orphan receptor βContactin-3Cell adhesion moleculeProtein 3BNeuronal typesSSC neuronsExpression patternsGene expressionMolecular mechanismsProtocadherin 20Gene 1Binding proteinCadherin-6Netrin-G2Calcium binding proteinMolecular families
2015
Functional Circuitry of the Retina
Demb JB, Singer JH. Functional Circuitry of the Retina. Annual Review Of Vision Science 2015, 1: 263-289. PMID: 28532365, PMCID: PMC5749398, DOI: 10.1146/annurev-vision-082114-035334.Peer-Reviewed Original ResearchGanglion cellsImportant model systemCell typesSynaptic excitationMammalian retinaParallel pathwaysMouse retinaModel systemNeural circuitryFunctional circuitryRetinaRetinal computationCellular compositionOutput neuronsBasic mechanismsApparent complexityDynamic balanceCellsStraightforward mechanismSpeciesPathwayInterneuronsMechanismNeuronsBrainFunction and Circuitry of VIP+ Interneurons in the Mouse Retina
Park SJ, Borghuis BG, Rahmani P, Zeng Q, Kim IJ, Demb JB. Function and Circuitry of VIP+ Interneurons in the Mouse Retina. Journal Of Neuroscience 2015, 35: 10685-10700. PMID: 26224854, PMCID: PMC4518048, DOI: 10.1523/jneurosci.0222-15.2015.Peer-Reviewed Original ResearchConceptsGanglion cell layerAmacrine cell typesInner nuclear layerAmacrine cellsGanglion cellsINL cellsON pathwayGanglion cell dendritesGanglion cell typesBipolar cell terminalsWhole-cell recordingsCell typesNervous system functionSpatial tuningBipolar cell pathwaysTransgenic mouse lineGCL cellsOptic nerveGABAergic interneuronsRetinal functionCell dendritesRetinal circuitryInhibitory interneuronsNuclear layerBipolar interneurons
2014
NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells
Stafford BK, Manookin MB, Singer JH, Demb JB. NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells. The Journal Of Physiology 2014, 592: 4877-4889. PMID: 25217374, PMCID: PMC4259533, DOI: 10.1113/jphysiol.2014.276543.Peer-Reviewed Original ResearchConceptsGanglion cellsNMDAR kineticsOFF alphaMammalian retinal ganglion cellsNMDA-type glutamate receptorsAMPAR-mediated responsesOFF alpha cellsGanglion cell typesRetinal ganglion cellsGuinea pig retinaNMDAR-mediated responsesBipolar cell pathwaysCell typesFast excitatory neurotransmissionGlutamatergic transmissionPresynaptic inhibitionGlutamate releaseSame synapsesSynaptic inhibitionGlutamate receptorsHz stimulationPostsynaptic AMPAExcitatory neurotransmissionSensory neuronsAMPA receptorsDevelopmental Changes in NMDA Receptor Subunit Composition at ON and OFF Bipolar Cell Synapses onto Direction-Selective Retinal Ganglion Cells
Stafford BK, Park SJ, Wong KY, Demb JB. Developmental Changes in NMDA Receptor Subunit Composition at ON and OFF Bipolar Cell Synapses onto Direction-Selective Retinal Ganglion Cells. Journal Of Neuroscience 2014, 34: 1942-1948. PMID: 24478373, PMCID: PMC3905152, DOI: 10.1523/jneurosci.4461-13.2014.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornExcitatory Amino Acid AgonistsFemaleGene Expression Regulation, DevelopmentalGlutamic AcidGreen Fluorescent ProteinsIn Vitro TechniquesLightMaleMembrane PotentialsMiceMice, Inbred C57BLMice, TransgenicNeurotransmitter AgentsN-MethylaspartatePatch-Clamp TechniquesReceptors, N-Methyl-D-AspartateRetinaRetinal Bipolar CellsRetinal Ganglion CellsSynapsesVisual PathwaysConceptsNMDA-type glutamate receptorsDirection-selective ganglion cellsExtrasynaptic NMDA-type glutamate receptorsNMDAR-mediated responsesBipolar cell synapsesGanglion cellsCell synapsesMature retinaSpecific ganglion cell typesDirection-selective retinal ganglion cellsNMDA receptor subunit compositionActivity-dependent synaptic developmentBipolar cell inputsGanglion cell typesRetinal ganglion cellsFirst postnatal monthReceptor subunit compositionWhole-cell recordingsGlutamatergic synapse formationCell typesGluN2B antagonist ifenprodilReceptor blockadeGlutamate releaseBipolar synapsesGlutamatergic synapses
2013
Transsynaptic Tracing with Vesicular Stomatitis Virus Reveals Novel Retinal Circuitry
Beier KT, Borghuis BG, El-Danaf RN, Huberman AD, Demb JB, Cepko CL. Transsynaptic Tracing with Vesicular Stomatitis Virus Reveals Novel Retinal Circuitry. Journal Of Neuroscience 2013, 33: 35-51. PMID: 23283320, PMCID: PMC3711516, DOI: 10.1523/jneurosci.0245-12.2013.Peer-Reviewed Original ResearchConceptsStarburst amacrine cellsVesicular stomatitis virusDirection-selective retinal ganglion cellsRetinal ganglion cell typesGanglion cell typesRetinal ganglion cellsStomatitis virusCell typesDensity of neuropilTranssynaptic tracerNeurotropic virusesPresynaptic sourceAmacrine cellsSynaptic relationshipsGanglion cellsRetinal circuitryPostsynaptic neuronsSynaptic partnersMouse retinaViral tracersCell type-specific dissectionNeural circuitsNeural circuitryViral spreadVirus
2012
Intrinsic properties and functional circuitry of the AII amacrine cell
DEMB JB, SINGER JH. Intrinsic properties and functional circuitry of the AII amacrine cell. Visual Neuroscience 2012, 29: 51-60. PMID: 22310372, PMCID: PMC3561778, DOI: 10.1017/s0952523811000368.Peer-Reviewed Original ResearchConceptsAII amacrine cellsAmacrine cellsPhotopic conditionsOFF ganglion cellsRod amacrine cellsCone bipolar cellsGanglion cell typesCone-mediated visionRod-mediated visionAII networkCell typesGanglion cellsRetinal neuronsExcitatory interneuronsBipolar cellsMammalian retinaFunctional circuitryAIIDistinct cell typesOutput neuronsNeuronsInhibition pathwayMotion sensitivityPhotoreceptor pathwaysCells
2010
NMDA Receptor Contributions to Visual Contrast Coding
Manookin MB, Weick M, Stafford BK, Demb JB. NMDA Receptor Contributions to Visual Contrast Coding. Neuron 2010, 67: 280-293. PMID: 20670835, PMCID: PMC2913150, DOI: 10.1016/j.neuron.2010.06.020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsContrast SensitivityDizocilpine MaleateElectric ConductivityExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsGene Expression RegulationGuinea PigsIn Vitro TechniquesLightMiceMice, Inbred C57BLN-MethylaspartatePatch-Clamp TechniquesPhotic StimulationPiperidinesReceptors, N-Methyl-D-AspartateRetinaRetinal Ganglion CellsVisual PerceptionConceptsNMDA receptorsOFF alphaAlpha cellsNMDA-type glutamate receptorsOFF alpha cellsDelta cellsGanglion cell typesNMDA receptor contributionCell typesExcitatory responsesGlutamate receptorsInhibitory currentsAMPA receptorsReceptor contributionGluN2B subunitContrast sensitivityContrast codingReceptorsNMDAAMPACertain cell typesCellsVisual processingAlphaInformation Processing: Contrast Sensitivity
Manookin M, Demb J. Information Processing: Contrast Sensitivity. 2010, 344-348. DOI: 10.1016/b978-0-12-374203-2.00199-8.Chapters