1999
Parkinson Disease in Twins
Parker W, Swerdlow R, Parks J, Davis J, Trimmer P, Bennett J, Wooten G. Parkinson Disease in Twins. JAMA 1999, 282: 1328-1329. PMID: 10527169, DOI: 10.1001/jama.282.14.1328.Peer-Reviewed Original Research
1998
Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family
Swerdlow R, Parks J, Davis J, Cassarino D, Trimmer P, Currie L, Dougherty J, Bridges W, Bennett J, Wooten G, Parker W. Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family. Annals Of Neurology 1998, 44: 873-881. PMID: 9851431, DOI: 10.1002/ana.410440605.Peer-Reviewed Original ResearchConceptsCybrid linesMaternal descendantsComplex I dysfunctionInherited mtDNA mutationsCybrid cell linesIncreased reactive oxygen species productionReactive oxygen species productionComplex I activityMitochondrial DNAMtDNA mutationsHuman neuroblastoma cellsFamily membersMitochondrial morphologyMtDNACytoplasmic hybridsPaternal descendantsOxygen species productionCybridsGenetic lesionsMatrilineal inheritanceMaternal lineMultiple membersI activityNeuroblastoma cellsEnzyme activity