2017
ASK1-dependent endothelial cell activation is critical in ovarian cancer growth and metastasis
Yin M, Zhou HJ, Zhang J, Lin C, Li H, Li X, Li Y, Zhang H, Breckenridge DG, Ji W, Min W. ASK1-dependent endothelial cell activation is critical in ovarian cancer growth and metastasis. JCI Insight 2017, 2: e91828. PMID: 28931753, PMCID: PMC5621912, DOI: 10.1172/jci.insight.91828.Peer-Reviewed Original ResearchConceptsTumor-associated macrophagesOvarian cancer growthOvarian cancerTranscoelomic metastasisCancer growthTumor growthOrthotopic ovarian cancer modelPeritoneal tumor growthInflammation-mediated tumorigenesisOvarian cancer modelEndothelial cell activationJunction protein VE-cadherinOvarian cancer progressionTAM infiltrationMacrophage infiltrationVascular leakageMacrophage transmigrationVascular permeabilityMouse modelVascular endotheliumMetastasis cancerTherapeutic targetMacrophage activationColon cancerCancer model
2015
AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis
Ji W, Li Y, He Y, Yin M, Zhou HJ, Boggon TJ, Zhang H, Min W. AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis. Cancer Research 2015, 75: 3492-3504. PMID: 26139244, PMCID: PMC4558200, DOI: 10.1158/0008-5472.can-15-0088.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsBreast NeoplasmsCarrier ProteinsCell Line, TumorEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticGuanylate KinasesHumansMelanoma, ExperimentalMiceNeoplasm MetastasisNeovascularization, PathologicProtein Kinase InhibitorsSignal TransductionTumor MicroenvironmentVascular Endothelial Growth Factor Receptor-2ConceptsEpithelial-mesenchymal transitionPremetastatic niche formationTumor growthAugments tumor growthBreast cancer modelSuppresses tumor progressionVascular endothelial cellsNiche formationSystemic administrationCancer modelVEGFR2 kinase inhibitorTumor neovascularizationTumor progressionTumor angiogenesisTumor microenvironmentTumor cellsEndothelial cellsMetastasisKinase inhibitorsTumor nicheVascular ECsSpecific deletionVascular environmentEMT switchAIP1 gene