2024
SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling
Xu Y, Zhang H, Chen Y, Pober J, Zhou M, Zhou J, Min W. SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling. Nature Communications 2024, 15: 6919. PMID: 39134547, PMCID: PMC11319592, DOI: 10.1038/s41467-024-51350-5.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSerum response factorCardiovascular diseaseVSMC synthetic phenotypeVascular remodelingNeointimal formationSENP1 deficiencySerum response factor activitySmooth muscle phenotypic switchingPhenotypic switchingPathogenesis of cardiovascular diseaseSmooth muscle cellsPost-translational SUMOylationTreatment of cardiovascular diseasesInhibitor AZD6244Phospho-ELK1Increased nuclear accumulationLysosomal localizationGene transcriptionNuclear accumulationMuscle cellsCoronary arteryCVD patientsVSMC phenotypic switchTherapeutic potential
2018
Endothelial AIP1 Regulates Vascular Remodeling by Suppressing NADPH Oxidase-2
Zhang J, Chen C, Li L, Zhou HJ, Li F, Zhang H, Yu L, Chen Y, Min W. Endothelial AIP1 Regulates Vascular Remodeling by Suppressing NADPH Oxidase-2. Frontiers In Physiology 2018, 9: 396. PMID: 29731721, PMCID: PMC5921534, DOI: 10.3389/fphys.2018.00396.Peer-Reviewed Original ResearchIntima-media thickeningVascular smooth muscle cellsEarly time pointsCytosolic subunit p47phoxLigation modelVascular remodelingReactive oxygen speciesVessel dysfunctionIntima/media ratioNOX2 complexMouse carotid artery ligation modelEndothelial cellsSubunit p47phoxCarotid artery ligation modelTime pointsNADPH oxidase 2Artery ligation modelROS productionHuman atherosclerotic plaquesSmooth muscle cellsCarotid ligation modelVSMC accumulationIntima areaApoE-KO mouse modelVascular disease