Diacylglycerol Kinase (DGK) Inhibitor II (R59949) Could Suppress Retinal Neovascularization and Protect Retinal Astrocytes in an Oxygen-Induced Retinopathy Model
Yang L, Xu Y, Li W, Yang B, Yu S, Zhou H, Yang C, Xu F, Wang J, Gao Y, Huang Y, Lu L, Liang X. Diacylglycerol Kinase (DGK) Inhibitor II (R59949) Could Suppress Retinal Neovascularization and Protect Retinal Astrocytes in an Oxygen-Induced Retinopathy Model. Journal Of Molecular Neuroscience 2014, 56: 78-88. PMID: 25451596, DOI: 10.1007/s12031-014-0469-2.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factorVascular endothelial growth factorRetinal neovascularizationRetinopathy modelHIF-1α/VEGF pathwayOxygen-induced retinopathy modelExposure of hyperoxiaSuppress retinal neovascularizationPostnatal day 7Endothelial growth factorProlyl hydroxylasesOIR miceOIR modelRetinal astrocytesIntraperitoneal injectionPathologic neovascularizationVEGF pathwayDay 7Astrocyte morphologyHIF-1αNeovascularizationPHD-2Room airHIF-α subunitsGrowth factor