2014
Diacylglycerol Kinase (DGK) Inhibitor II (R59949) Could Suppress Retinal Neovascularization and Protect Retinal Astrocytes in an Oxygen-Induced Retinopathy Model
Yang L, Xu Y, Li W, Yang B, Yu S, Zhou H, Yang C, Xu F, Wang J, Gao Y, Huang Y, Lu L, Liang X. Diacylglycerol Kinase (DGK) Inhibitor II (R59949) Could Suppress Retinal Neovascularization and Protect Retinal Astrocytes in an Oxygen-Induced Retinopathy Model. Journal Of Molecular Neuroscience 2014, 56: 78-88. PMID: 25451596, DOI: 10.1007/s12031-014-0469-2.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factorVascular endothelial growth factorRetinal neovascularizationRetinopathy modelHIF-1α/VEGF pathwayOxygen-induced retinopathy modelExposure of hyperoxiaSuppress retinal neovascularizationPostnatal day 7Endothelial growth factorProlyl hydroxylasesOIR miceOIR modelRetinal astrocytesIntraperitoneal injectionPathologic neovascularizationVEGF pathwayDay 7Astrocyte morphologyHIF-1αNeovascularizationPHD-2Room airHIF-α subunitsGrowth factor
2013
Functional Analyses of TNFR2 in Physiological and Pathological Retina AngiogenesisTNFR2 Mediates Retinal Angiogenesis
Wan T, Xu Z, Zhou HJ, Zhang H, Luo Y, Li Y, Min W. Functional Analyses of TNFR2 in Physiological and Pathological Retina AngiogenesisTNFR2 Mediates Retinal Angiogenesis. Investigative Ophthalmology & Visual Science 2013, 54: 211-221. PMID: 23188724, PMCID: PMC3544528, DOI: 10.1167/iovs.12-10364.Peer-Reviewed Original ResearchMeSH KeywordsAngiopoietin-2AnimalsAnimals, NewbornCell SurvivalDisease Models, AnimalEndothelium, VascularEpithelial CellsGene ExpressionHumansHypoxiaInfant, NewbornMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNeovascularization, PathologicNF-kappa BOxygenProtein-Tyrosine KinasesReceptor, TIE-2Receptors, Tumor Necrosis Factor, Type IIRetinaRetinal NeovascularizationRetinopathy of PrematurityVascular Endothelial Growth Factor Receptor-2ConceptsTumor necrosis factor receptor 2Wild-type C57BL/6 miceTNFR2 deletionTNFR2-KOOIR modelOxygen-induced retinopathy modelNecrosis factor receptor 2Pathological neovascular tuftsRetinal vascular repairVascular ECsRetinal vascular developmentIschemia-induced revascularizationRetinal vasculature developmentFactor receptor 2Vascular endothelial cellsPreretinal neovascularizationVascular developmentC57BL/6 miceNeovascular tuftsKO miceNeonatal miceIsolectin stainingVascular repairBone marrow kinasePostnatal day
2012
TMP Prevents Retinal Neovascularization and Imparts Neuroprotection in an Oxygen-Induced Retinopathy ModelTMP Blocks Oxygen-Induced Retinopathy
Liang X, Zhou H, Ding Y, Li J, Yang C, Luo Y, Li S, Sun G, Liao X, Min W. TMP Prevents Retinal Neovascularization and Imparts Neuroprotection in an Oxygen-Induced Retinopathy ModelTMP Blocks Oxygen-Induced Retinopathy. Investigative Ophthalmology & Visual Science 2012, 53: 2157-2169. PMID: 22410554, PMCID: PMC4627509, DOI: 10.1167/iovs.11-9315.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornApoptosisDisease Models, AnimalDrugs, Chinese HerbalFluorescent Antibody Technique, IndirectGlial Fibrillary Acidic ProteinHypoxia-Inducible Factor 1, alpha SubunitIn Situ Nick-End LabelingLigusticumMiceMice, Inbred C57BLMicroscopy, ConfocalNerve Tissue ProteinsNeuroprotective AgentsOxygenPyrazinesReperfusion InjuryRetinal NeovascularizationRetinal NeuronsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerVascular Endothelial Growth Factor AVasodilator AgentsConceptsEffects of tetramethylpyrazineVEGF mRNA expressionCell bodiesRetinal neovascularizationAvascular retinaMüller cellsMouse retinaHIF-1αMRNA expressionOxygen-induced retinopathy modelIschemia-induced cell deathHorizontal cell bodiesNeonatal C57BL/6J miceOuter plexiform layerPostnatal day 7Amacrine cell bodiesTUNEL-positive cellsMüller cell bodiesImparts NeuroprotectionNeurovascular recoveryNeurovascular repairControl miceC57BL/6J micePlexiform layerNormal saline