Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer
Yin M, Li X, Tan S, Zhou HJ, Ji W, Bellone S, Xu X, Zhang H, Santin AD, Lou G, Min W. Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer. Journal Of Clinical Investigation 2016, 126: 4157-4173. PMID: 27721235, PMCID: PMC5096908, DOI: 10.1172/jci87252.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsErbB ReceptorsFemaleHeterograftsHumansIntercellular Adhesion Molecule-1Macrophage-1 AntigenMacrophagesMiceMice, NudeNeoplasm MetastasisNeoplasm ProteinsNeoplasm TransplantationOvarian NeoplasmsSpheroids, CellularVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1ConceptsTumor-associated macrophagesOvarian cancerTranscoelomic metastasisTumor cellsICAM-1Mouse modelEpithelial ovarian cancerOvarian cancer growthOvarian cancer metastasisSpheroid formationOvarian cancer progressionVEGF/VEGFRTumor cell proliferationPharmacological blockadeMetastatic cancerColon cancerCancer growthMetastasisAntibody neutralizationTumor growthCancerClinical pathologyCancer metastasisCancer progressionΑMβ2 integrinMitochondrial Redox Signaling and Tumor Progression
Chen Y, Zhang H, Zhou HJ, Ji W, Min W. Mitochondrial Redox Signaling and Tumor Progression. Cancers 2016, 8: 40. PMID: 27023612, PMCID: PMC4846849, DOI: 10.3390/cancers8040040.Peer-Reviewed Original ResearchMitochondrial redox proteinsExcessive ROSRedox proteinsCancer cellsMitochondrial redox signalingMitochondrial oxidative phosphorylationCellular ROS levelsStress signalingRedox regulationROS functionTumor progressionRedox signalingMitochondrial roleApoptotic signalingCancer cell proliferationRedox-sensitive pathwaysTranscriptional factorsReactive oxygen species generationTumor suppressorOxidative phosphorylationDNA mutationsOxygen species generationCancer progressionBasal ROSCancer invasion