ASK family in cardiovascular biology and medicine
Liu T, Zhou HJ, Min W. ASK family in cardiovascular biology and medicine. Advances In Biological Regulation 2017, 66: 54-62. PMID: 29107568, PMCID: PMC5705453, DOI: 10.1016/j.jbior.2017.10.011.Peer-Reviewed Original ResearchConceptsProtein kinase signalsMAPK signal cascadeCellular functionsKinase signalsSignal cascadeCell survivalCardiovascular biologyASK1Signal pathwayKey moleculesNovel therapeutic strategiesPathwayCrucial roleASK3MAPKKKASK2Therapeutic strategiesCardiovascular pathophysiologyBiologyApoptosisMitogenRegulationCurrent reviewCascadeProliferationMechanistic Role of Thioredoxin 2 in Heart Failure
Chen C, Chen H, Zhou HJ, Ji W, Min W. Mechanistic Role of Thioredoxin 2 in Heart Failure. Advances In Experimental Medicine And Biology 2017, 982: 265-276. PMID: 28551792, DOI: 10.1007/978-3-319-55330-6_14.Peer-Reviewed Original ResearchConceptsThioredoxin 2ASK1-dependent apoptosisMechanistic roleMitochondrial reactive oxygen species generationCellular oxidative stressGlobal gene knockoutMitochondrial proteinsEmbryonic lethalityMitochondrial Trx2Gene knockoutKinase 1Reactive oxygen species generationTrx2Key mechanistic roleOxygen species generationCardiomyocyte apoptosisActive tissuesApoptosisCommon mechanismOxidative stressSpecies generationPromising targetHeart failureTherapeutic strategiesTreatment of DCM