2014
Dopamine D3 receptor alterations in cocaine-dependent humans imaged with [11C](+)PHNO
Matuskey D, Gallezot JD, Pittman B, Williams W, Wanyiri J, Gaiser E, Lee DE, Hannestad J, Lim K, Zheng MQ, Lin SF, Labaree D, Potenza MN, Carson RE, Malison RT, Ding YS. Dopamine D3 receptor alterations in cocaine-dependent humans imaged with [11C](+)PHNO. Drug And Alcohol Dependence 2014, 139: 100-105. PMID: 24717909, PMCID: PMC4071607, DOI: 10.1016/j.drugalcdep.2014.03.013.Peer-Reviewed Original ResearchConceptsCocaine dependenceCD subjectsIllicit substance abuseHealthy control subjectsCocaine-dependent humansGroup differencesHistory of cocaineReference tissue modelDopaminergic transmissionReceptor alterationsSubstantia nigraControl subjectsAnimal modelsReceptor availabilityEarly abstinenceCocaine useSubstance abuseBPND valuesAvailable receptorsPilot studyAmygdalaReference regionPallidumReceptorsPotential relevance
2013
Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[11C]O-methylreboxetine
Li CS, Potenza MN, Lee DE, Planeta B, Gallezot JD, Labaree D, Henry S, Nabulsi N, Sinha R, Ding YS, Carson RE, Neumeister A. Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[11C]O-methylreboxetine. NeuroImage 2013, 86: 306-310. PMID: 24121204, PMCID: PMC3947246, DOI: 10.1016/j.neuroimage.2013.10.004.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Norepinephrine transporterNoradrenergic dysfunctionObese individualsLean individualsStructural MR scansBPND valuesNorepinephrine transporter availabilityReference tissue model 2Positron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyBrain norepinephrine transportersNE clearanceMass indexRaphe nucleusLocus coeruleusSynaptic availabilityObese peopleTransporter availabilityOccipital cortexComparison subjectsHealthy individualsObesity
2011
Serotonin 1B receptor imaging in pathological gambling
Potenza MN, Walderhaug E, Henry S, Gallezot JD, Planeta-Wilson B, Ropchan J, Neumeister A. Serotonin 1B receptor imaging in pathological gambling. The World Journal Of Biological Psychiatry 2011, 14: 139-145. PMID: 21936763, PMCID: PMC3595502, DOI: 10.3109/15622975.2011.598559.Peer-Reviewed Original ResearchConceptsSerotonin 1B receptorAnterior cingulate cortexPathological gamblingCingulate cortexVentral striatumBPND valuesMedication-free subjectsSouth Oaks Gambling ScreenPositron emission scanningFunctional neuroimaging studiesSerotonergic mechanismsSerotonergic functionSerotonin receptorsCC subjectsComparison subjectsBrain regionsImaging studiesPG subjectsNeuroimaging studiesPotential roleReceptorsFurther studiesStriatumSubstance addictionCortex