2020
Social supports moderate the effects of child adversity on neural correlates of threat processing
Wymbs NF, Orr C, Albaugh MD, Althoff RR, O’Loughlin K, Holbrook H, Garavan H, Montalvo-Ortiz JL, Mostofsky S, Hudziak J, Kaufman J. Social supports moderate the effects of child adversity on neural correlates of threat processing. Child Abuse & Neglect 2020, 102: 104413. PMID: 32065988, PMCID: PMC8060780, DOI: 10.1016/j.chiabu.2020.104413.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingThreat processingAnterior cingulate cortexSocial supportEmotion regulationNeural correlatesEmotional Go-Nogo taskGo-NoGo taskPositive social supportChildren ages 7Forms of adversityKey brain regionsAdverse experiencesFacial stimuliThreat stimuliNeural processingBrain systemsBrain activationModerate adversitySevere adversityAnterior insulaConjunction analysisLeft amygdalaOrbitofrontal cortexActivation foci
2015
RDoC and translational perspectives on the genetics of trauma‐related psychiatric disorders
Montalvo-Ortiz JL, Gelernter J, Hudziak J, Kaufman J. RDoC and translational perspectives on the genetics of trauma‐related psychiatric disorders. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 171: 81-91. PMID: 26592203, PMCID: PMC4754782, DOI: 10.1002/ajmg.b.32395.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsStress-related psychiatric disordersPsychiatric disordersTrauma-related psychiatric disordersAdverse early life experiencesSubstance use disordersGenetic risk factorsKey brain structuresDistinct neural circuitsDistinct psychiatric disordersSubstance use problemsClinical syndromeRisk factorsHigh riskPsychiatric problemsUse disordersAdverse early experiencesTranslational studiesGenome-wide association studiesClinical phenotypeNeural circuitsBrain structuresResearch Domain Criteria frameworkCircuitry developmentEarly life experiencesAnxiety disorders