2022
Differential Role of mGluR5 in Cognitive Processes in Posttraumatic Stress Disorder and Major Depression
Esterlis I, DeBonee S, Cool R, Holmes S, Baldassari SR, Maruff P, Pietrzak RH, Davis MT. Differential Role of mGluR5 in Cognitive Processes in Posttraumatic Stress Disorder and Major Depression. Chronic Stress 2022, 6: 24705470221105804. PMID: 35958037, PMCID: PMC9358555, DOI: 10.1177/24705470221105804.Peer-Reviewed Original ResearchPosttraumatic stress disorderMajor depressive disorderHealthy adultsCognitive functioningFrontolimbic regionsStress disorderCognitive AssessmentCognitive alterationsPoor attentionCognitionMGluR5 availabilityRobust literatureDiagnostic groupsDifferent domainsMetabotropic glutamate receptor type 5Positron emission tomography scanDepressive disorderEmission tomography scanDisordersFunctioningRelationshipSmoking statusTomography scanParticipantsAdults
2021
Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans
Angarita GA, Worhunsky PD, Naganawa M, Toyonaga T, Nabulsi NB, Li C, Esterlis I, Skosnik PD, Radhakrishnan R, Pittman B, Gueorguieva R, Potenza MN, Finnema SJ, Huang Y, Carson RE, Malison RT. Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans. Addiction Biology 2021, 27: e13123. PMID: 34852401, PMCID: PMC8891080, DOI: 10.1111/adb.13123.Peer-Reviewed Original ResearchConceptsCocaine use disorderAnterior cingulate cortexRecent cocaine useSynaptic densityMedial orbitofrontal cortexPrefrontal cortexCocaine useOrbitofrontal cortexUse disordersVentromedial prefrontal cortexPositron emission tomography scanPositron emission tomography studyEmission tomography scanSynaptic vesicle glycoprotein 2AHealthy control subjectsVolume of distributionEmission tomography studiesAcute cocaineControl subjectsTomography scanCocaine exposurePreclinical studiesHC subjectsDendritic spinesLifetime cocaine use