2020
Ketamine Normalizes the Structural Alterations of Inferior Frontal Gyrus in Depression
Dai D, Lacadie CM, Holmes SE, Cool R, Anticevic A, Averill C, Abdallah C, Esterlis I. Ketamine Normalizes the Structural Alterations of Inferior Frontal Gyrus in Depression. Chronic Stress 2020, 4: 2470547020980681. PMID: 33426409, PMCID: PMC7758564, DOI: 10.1177/2470547020980681.Peer-Reviewed Original ResearchMajor depressive disorderPost-traumatic stress disorderMagnetic resonance imagingAcute ketamine administrationKetamine administrationKetamine infusionMDD subjectsInferior frontal gyrusComorbid post-traumatic stress disorderPTSD groupAcute ketamine treatmentFrontal gyrusHealthy control subjectsIntravenous ketamine infusionRegional volume differencesImpact of ketamineSingle ketamine infusionStructural alterationsFuture therapeutic targetsVoxel-wise t-testsKetamine treatmentControl subjectsDepressive disorderHC groupPTSD subjects
2019
Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET
Holmes SE, Gallezot JD, Davis MT, DellaGioia N, Matuskey D, Nabulsi N, Krystal JH, Javitch JA, DeLorenzo C, Carson RE, Esterlis I. Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 2254-2264. PMID: 31744389, PMCID: PMC7585925, DOI: 10.1177/0271678x19886316.Peer-Reviewed Original ResearchConceptsEffects of ketamineKetamine infusionGlutamate transmissionMetabotropic glutamate receptor 5Ketamine-induced effectsKetamine-induced changesGlutamate receptor 5Promising treatment targetDrug challenge studiesTwo-tissue compartment modelMGluR5 radioligandBlood pressureMGluR5 availabilityBaseline scanOutcome measuresHealthy subjectsHeart ratePsychiatric disordersReceptor 5Modulatory effectsMGluR5Treatment targetsChallenge studiesArterial input functionChallenge paradigm