2022
Differential Role of mGluR5 in Cognitive Processes in Posttraumatic Stress Disorder and Major Depression
Esterlis I, DeBonee S, Cool R, Holmes S, Baldassari SR, Maruff P, Pietrzak RH, Davis MT. Differential Role of mGluR5 in Cognitive Processes in Posttraumatic Stress Disorder and Major Depression. Chronic Stress 2022, 6: 24705470221105804. PMID: 35958037, PMCID: PMC9358555, DOI: 10.1177/24705470221105804.Peer-Reviewed Original ResearchPosttraumatic stress disorderMajor depressive disorderHealthy adultsCognitive functioningFrontolimbic regionsStress disorderCognitive AssessmentCognitive alterationsPoor attentionCognitionMGluR5 availabilityRobust literatureDiagnostic groupsDifferent domainsMetabotropic glutamate receptor type 5Positron emission tomography scanDepressive disorderEmission tomography scanDisordersFunctioningRelationshipSmoking statusTomography scanParticipantsAdults
2020
Depression and Cognitive Dysfunction in Older U.S. Military Veterans: Moderating Effects of BDNF Val66Met Polymorphism and Physical Exercise
Pitts BL, Wen V, Whealin JM, Fogle BM, Southwick SM, Esterlis I, Pietrzak RH. Depression and Cognitive Dysfunction in Older U.S. Military Veterans: Moderating Effects of BDNF Val66Met Polymorphism and Physical Exercise. American Journal Of Geriatric Psychiatry 2020, 28: 959-967. PMID: 32122804, DOI: 10.1016/j.jagp.2020.02.001.Peer-Reviewed Original ResearchConceptsU.S. military veteransVisual learningCognitive functioningMet allele carriersMilitary veteransObjective measuresSubjective cognitive measuresSubjective measuresCognitive dysfunctionEffect of depressionVal66Met genotypeCognitive measuresCognitive AssessmentProcessing speedCognitive functionBDNF Val66Met polymorphismPhysical exerciseVal/ValBDNF Val66Met genotypeFunctioningTreatment effortsModerate decrementsAnalysis of covarianceInteractive effectsLearning