Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice
Kim J, Chung K, Choi C, Beloor J, Ullah I, Kim N, Lee KY, Lee SK, Kumar P. Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice. Molecular Therapy - Nucleic Acids 2016, 5: e280. PMID: 26812653, PMCID: PMC5012549, DOI: 10.1038/mtna.2015.51.Peer-Reviewed Original ResearchAdipose tissueHigh-fat diet-induced obesityPeripheral monocytes/macrophagesObesity-related metabolic diseasesAssociated metabolic syndromeAdipose tissue inflammationAdverse metabolic outcomesObesity-associated inflammationDietary obese miceDiet-induced obesityObese adipose tissueSpecific monocyte subsetsHepatic triglyceride productionRecruitment of macrophagesGene knockdown strategyMonocytes/macrophagesTissue-resident macrophagesInsulin sensitivity profileDietary obesityMetabolic syndromeGlucose toleranceMacrophage infiltrationObese miceProinflammatory cytokinesHepatic steatosis