Blocking Fas-signaling in adipocytes and hepatocytes prevents obesity-associated inflammation, insulin resistance, and hepatosteatosis
Bae S, Ullah I, Beloor J, Lim J, Chung K, Yi Y, Kang E, Yun G, Rhim T, Lee S. Blocking Fas-signaling in adipocytes and hepatocytes prevents obesity-associated inflammation, insulin resistance, and hepatosteatosis. Journal Of Industrial And Engineering Chemistry 2024, 135: 434-443. DOI: 10.1016/j.jiec.2024.01.055.Peer-Reviewed Original ResearchFas signalingObese mouse modelInhibit Fas signalingFas-mediated apoptosisObesity-associated inflammationFas-signalingInsulin resistanceAdipose tissueMouse modelHepatic steatosisMetabolic dysfunctionSystemic free fatty acidsPro-inflammatory cytokine secretionReduced apoptosisApoptosisFatty acidsReversible inflammationSystemic deliveryCytokine secretionLiver functionInflammatory pathwaysFree fatty acidsLiver steatosisInflammationHepatic triglycerideIntranasal Delivery of Anti-Apoptotic siRNA Complexed with Fas-Signaling Blocking Peptides Attenuates Cellular Apoptosis in Brain Ischemia
Chung K, Ullah I, Yi Y, Kang E, Yun G, Heo S, Kim M, Chung S, Park S, Lim J, Lee M, Rhim T, Lee S. Intranasal Delivery of Anti-Apoptotic siRNA Complexed with Fas-Signaling Blocking Peptides Attenuates Cellular Apoptosis in Brain Ischemia. Pharmaceutics 2024, 16: 290. PMID: 38399343, PMCID: PMC10892455, DOI: 10.3390/pharmaceutics16020290.Peer-Reviewed Original ResearchExtrinsic apoptosis pathwayIntrinsic apoptosis pathwayApoptosis pathwayNeuronal cell deathRelease of cytochrome c.Cell deathInhibit Fas signalingNona-arginine peptideFas-signalingFas signalingConfocal microscopy analysisMitochondria disruptionMiddle cerebral artery occlusionFas receptorIntrinsic pathwayTargeting BaxCytochrome c.Molecular mechanismsCellular apoptosisLigand signalingBaxBrain ischemiaPathwayTreatment of brain ischemiaSiRNA complexes