Triple-negative breast cancer: epidemiology, molecular mechanisms, and modern vaccine-based treatment strategies
Karim A, Eun Kwon J, Ali T, Jang J, Ullah I, Lee Y, Park D, Park J, Jeang J, Kang S. Triple-negative breast cancer: epidemiology, molecular mechanisms, and modern vaccine-based treatment strategies. Biochemical Pharmacology 2023, 212: 115545. PMID: 37044296, DOI: 10.1016/j.bcp.2023.115545.Peer-Reviewed Original ResearchConceptsTriple-negative breast cancerGenome modificationBreast cancerDevelopmental signaling pathwaysCases of breast cancerGenome sequenceEstrogen receptor expressionBreast tumor subtypesOverexpression of HER2Unique mutational profileRecurring mutationsAbsence of progesteroneRare mutationsSusceptibility genesBRCA1/2 genesSignaling pathwayMolecular mechanismsGene amplificationReceptor expressionTumor subtypesPoor prognosisTumor heterogeneityMutation profilesTherapeutic strategiesGermline modification