2019
Extracellular matrix-derived biomaterials in engineering cell function
Xing H, Lee H, Luo L, Kyriakides TR. Extracellular matrix-derived biomaterials in engineering cell function. Biotechnology Advances 2019, 42: 107421. PMID: 31381963, PMCID: PMC6995418, DOI: 10.1016/j.biotechadv.2019.107421.Peer-Reviewed Educational MaterialsConceptsTissue-derived extracellular matrixECM proteinsExtracellular matrixCell-derived extracellular matrixSingle ECM proteinsStem cell differentiationCell functionCell-specific responsesGuide cell migrationEngineering of biomaterialsCell differentiationECM environmentECM polymersCell adhesionNative stateCell migrationProteinUse of biomaterialsMaterial coatingEnhanced cell adhesionBiomaterialsCell isolationDecellularization technologyRecent advancesDermal repairThrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29
Calabro NE, Barrett A, Chamorro-Jorganes A, Tam S, Kristofik NJ, Xing H, Loye AM, Sessa WC, Hansen K, Kyriakides TR. Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29. Matrix Biology 2019, 82: 71-85. PMID: 30876926, PMCID: PMC6710120, DOI: 10.1016/j.matbio.2019.03.002.Peer-Reviewed Original ResearchConceptsECM protein productionProtein productionLysyl oxidaseThrombospondin-2MiR-29Matricellular proteinQuantitative proteomics approachLevels of LOXExtracellular matrix productionProteomic approachECM proteinsMajor regulatorECM homeostasisExtracellular matrixMatrix productionProteinCollagen fibrillogenesisMiR-29 expressionFibrillar collagenImportant modulatorDependent processesLOX levelsRegulatorProductionHomeostasis
2017
Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways
Li R, Hebert J, Lee T, Xing H, Boussommier-Calleja A, Hynes R, Lauffenburger D, Kamm R. Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways. Cancer Research 2017, 77: 279-290. PMID: 27872091, PMCID: PMC5243269, DOI: 10.1158/0008-5472.can-16-0442.Peer-Reviewed Original ResearchConceptsCancer cellsExtracellular matrixCancer cell migrationMigration speedCancer cell metastasisCell migration assayMigration persistenceSolid tumorsPersistence of cancer cellsCell migrationMT1-MMP expressionSynergistic inductionDeterminants of metastasisCell metastasisMT1-MMPMigration assayPresence of macrophagesAntimetastatic strategyDual blockadeTumor microenvironmentTissue cultureTGFB1Dense extracellular matrixCellsMetastasis