Mitochondrial Dysfunction, Insulin Resistance, and Potential Genetic Implications
Sangwung P, Petersen KF, Shulman GI, Knowles JW. Mitochondrial Dysfunction, Insulin Resistance, and Potential Genetic Implications. Endocrinology 2020, 161: bqaa017. PMID: 32060542, PMCID: PMC7341556, DOI: 10.1210/endocr/bqaa017.Peer-Reviewed Original ResearchConceptsInsulin resistanceWhole-body insulin resistanceMitochondrial functionEctopic lipid depositionBody insulin resistanceType 2 diabetesWhite adipose tissuePrediabetic individualsVivo metabolic studiesInsulin-responsive tissuesLipid depositionAdipose tissueType 2Skeletal muscleMitochondrial dysfunctionPotential mechanismsMetabolic studiesHuman genetic studiesTissueEnvironmental determinantsMitochondrial malfunctionCellular energy balanceRecent insightsCritical roleDiabetes