2021
Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease
Pointer TC, Gorelick FS, Desir GV. Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease. Cells 2021, 10: 2006. PMID: 34440775, PMCID: PMC8391834, DOI: 10.3390/cells10082006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGastrointestinal DiseasesGastrointestinal TractHumansMonoamine OxidaseProtein IsoformsSignal TransductionConceptsProsurvival effectAcute cerulein pancreatitisRole of renalaseAnti-inflammatory effectsDisease modelsAcute organ injuryRelevant clinical settingsShortens life expectancyPreclinical disease modelsCell survivalHuman cancer tissuesCancer cell survivalOrgan injuryAcute injuryPancreatic cancerIntestinal diseaseGastrointestinal diseasesRodent modelsCerulein pancreatitisSelect cancersCancer tissuesRenalaseClinical settingTherapeutic agentsExport transporters
2008
The novel protein kinase C isoforms -δ and -ε modulate caerulein-induced zymogen activation in pancreatic acinar cells
Thrower EC, Osgood S, Shugrue CA, Kolodecik TR, Chaudhuri AM, Reeve JR, Pandol SJ, Gorelick FS. The novel protein kinase C isoforms -δ and -ε modulate caerulein-induced zymogen activation in pancreatic acinar cells. AJP Gastrointestinal And Liver Physiology 2008, 294: g1344-g1353. PMID: 18388183, PMCID: PMC2975015, DOI: 10.1152/ajpgi.00020.2008.Peer-Reviewed Original ResearchConceptsAcute pancreatitisPancreatic acinar cellsAcinar cellsNM caeruleinInitiation of APProtein kinase CCaerulein-induced acute pancreatitisPremature zymogen activationPKC-epsilonSupraphysiological effectsInflammatory mediatorsIsoform-specific PKC inhibitorsPathological secretionPKC-deltaCaerulein administrationPancreatic tissueHormone cholecystokininSupranuclear regionVivo studiesCaerulein stimulationAcinar cell compartmentNovel protein kinase C isoformsActivator of PKCZymogen activationProtein kinase C in the pancreatic acinar cell
Gorelick F, Pandol S, Thrower E. Protein kinase C in the pancreatic acinar cell. Journal Of Gastroenterology And Hepatology 2008, 23: s37-s41. PMID: 18336661, DOI: 10.1111/j.1440-1746.2007.05282.x.Peer-Reviewed Original ResearchConceptsProtein kinase CKinase CCell-free reconstitution systemPancreatic acinar cellsAcinar cellsPathological responseSpecific PKC isoformsPathogenesis of pancreatitisReconstitution systemCellular eventsPKC isoformsActivation of proteasesApical secretionProtease activationCell eventsInflammatory mediatorsAcute pancreatitisPathological activationSupraphysiological concentrationsPancreatitisPathological effectsPancreatic aciniCholecystokininCellsActivation