1998
Clinical Value of Acute Rest Technetium-99m Tetrofosmin Tomographic Myocardial Perfusion Imaging in Patients With Acute Chest Pain and Nondiagnostic Electrocardiograms
Heller G, Stowers S, Hendel R, Herman S, Daher E, Ahlberg A, Baron J, de Leon C, Rizzo J, Wackers F. Clinical Value of Acute Rest Technetium-99m Tetrofosmin Tomographic Myocardial Perfusion Imaging in Patients With Acute Chest Pain and Nondiagnostic Electrocardiograms. Journal Of The American College Of Cardiology 1998, 31: 1011-1017. PMID: 9562001, DOI: 10.1016/s0735-1097(98)00057-6.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTomographic myocardial perfusionMyocardial infarctionChest painNondiagnostic electrocardiogramEmergency departmentHospital periodHospital admissionRest technetiumTetrofosmin SPECTMyocardial perfusionLow cardiac event rateTetrofosmin single photon emissionMultiple logistic regression analysisAcute chest painCardiac event rateNormal SPECT imagesMean cost savingsUnnecessary hospital admissionsLogistic regression analysisSingle photon emissionSPECT imagesAbnormal SPECTCardiac eventsRest Tc
1997
Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease
Khattar R, Hendel R, Crawley J, Wackers F, Rigo P, Zaret B, Sridhara B, Lahiri A. Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease. Journal Of Nuclear Cardiology 1997, 4: 291-297. PMID: 9278875, DOI: 10.1016/s1071-3581(97)90106-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCoronary DiseaseFemaleHumansMaleMiddle AgedOrganophosphorus CompoundsOrganotechnetium CompoundsRadionuclide ImagingThallium RadioisotopesConceptsCoronary artery diseaseROC curve analysisPrevious myocardial infarctionArtery diseaseCurve analysisMyocardial infarctionMulticenter phase III trialTechnetium 99m-labeled tetrofosminDiagnostic accuracySingle-vessel diseasePhase III trialsCharacteristic curve analysisMultivessel diseaseIII trialsCoronary arteriographyROC curve areaThallium-201TetrofosminDiagnostic testsDiseaseDiagnostic performanceCurve areaInfarctionReference standardPlanar imaging
1996
Quantitative comparison of planar and SPECT normal data files of thallium-201, technetium-99m-sestamibi, technetium-99m-tetrofosmin and technetium-99m-furifosmin.
Naruse H, Daher E, Sinusas A, Jain D, Natale D, Mattera J, Makuch R, Wackers FJ. Quantitative comparison of planar and SPECT normal data files of thallium-201, technetium-99m-sestamibi, technetium-99m-tetrofosmin and technetium-99m-furifosmin. Journal Of Nuclear Medicine 1996, 37: 1783-8. PMID: 8917175.Peer-Reviewed Original Research
1995
Myocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group.
Zaret B, Rigo P, Wackers F, Hendel R, Braat S, Iskandrian A, Sridhara B, Jain D, Itti R, Serafini A, Goris M, Lahiri A. Myocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group. Circulation 1995, 91: 313-9. PMID: 7805233, DOI: 10.1161/01.cir.91.2.313.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseaseTetrofosmin imagingCoronary angiographyMyocardial perfusionTetrofosmin imagesHealthy subjectsPhase III multicenter trialConventional myocardial perfusionLower likelihoodCentral core laboratoryMyocardial perfusion abnormalitiesNew 99mTcPeak heart rateNegative predictive accuracyMyocardial perfusion imagingNew myocardial imaging agentPlanar 201TlMulticenter trialNormalcy rateCoronary angiogramDouble productPerfusion abnormalitiesMyocardial imaging agentRadiotracer injection
1994
Reduced variability of interpretation and improved image quality with a technetium 99m myocardial perfusion agent: Comparison of thallium 201 and technetium 99m-labeled tetrofosmin
Hendel R, Parker M, Wackers F, Rigo P, Lahiri A, Zaret B. Reduced variability of interpretation and improved image quality with a technetium 99m myocardial perfusion agent: Comparison of thallium 201 and technetium 99m-labeled tetrofosmin. Journal Of Nuclear Cardiology 1994, 1: 509-514. PMID: 9420744, DOI: 10.1007/bf02939973.Peer-Reviewed Original ResearchCoronary DiseaseHeartHumansOrganophosphorus CompoundsOrganotechnetium CompoundsRadionuclide ImagingThallium RadioisotopesTechnetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia.
Sinusas AJ, Shi Q, Saltzberg MT, Vitols P, Jain D, Wackers FJ, Zaret BL. Technetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia. Journal Of Nuclear Medicine 1994, 35: 664-71. PMID: 8151391.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAnimalsCoronary CirculationDogsHeartMyocardial IschemiaOrganophosphorus CompoundsOrganotechnetium CompoundsRadionuclide ImagingConceptsTechnetium-99mCanine modelPerfusion tracerMicrosphere flowCoronary artery occlusionInitial myocardial uptakeIntact canine modelOpen-chest dogsMyocardial perfusion imagingMyocardial blood flowDynamic planar imagingArtery occlusionPharmacological vasodilatationPharmacological stressMyocardial perfusion tracersMyocardial uptakeRadiotracer injectionBlood flowMyocardial perfusionPerfusion imagingArterial samplingMyocardial flowBackground activity ratioTetrofosminIschemiaThe maze of myocardial perfusion imaging protocols in 1994
Wackers F. The maze of myocardial perfusion imaging protocols in 1994. Journal Of Nuclear Cardiology 1994, 1: 180-188. PMID: 9420685, DOI: 10.1007/bf02984090.Peer-Reviewed Original ResearchMeSH KeywordsHeartHumansOrganophosphorus CompoundsOrganotechnetium CompoundsOximesRadionuclide ImagingTechnetium Tc 99m SestamibiThallium Radioisotopes
1993
Biokinetics of technetium-99m-tetrofosmin: myocardial perfusion imaging agent: implications for a one-day imaging protocol.
Jain D, Wackers FJ, Mattera J, McMahon M, Sinusas AJ, Zaret BL. Biokinetics of technetium-99m-tetrofosmin: myocardial perfusion imaging agent: implications for a one-day imaging protocol. Journal Of Nuclear Medicine 1993, 34: 1254-9. PMID: 8326381.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCoronary DiseaseExercise TestFemaleHumansMaleMiddle AgedOrganophosphorus CompoundsOrganotechnetium CompoundsRadionuclide ImagingTime FactorsConceptsOrgan ratiosGastrointestinal tractRest imagesImaging protocolSymptom-limited treadmill exerciseDecay-corrected countsLeft anterior oblique viewStress imagesAnterior oblique viewPortion of liverOptimal imaging protocolMyocardial perfusion imaging agentPeak exerciseTreadmill exerciseClinical trialsTechnetium-99mRadiotracer injectionMyocardial perfusionTetrofosmin imagesGallbladderPhase IEntire heartLiverTractOblique view