2015
Autonomic dysfunction independently predicts poor cardiovascular outcomes in asymptomatic individuals with type 2 diabetes in the DIAD study
Chyun DA, Wackers FJ, Inzucchi SE, Jose P, Weiss C, Davey JA, Heller GV, Iskandrian AE, Young LH, Investigators F. Autonomic dysfunction independently predicts poor cardiovascular outcomes in asymptomatic individuals with type 2 diabetes in the DIAD study. SAGE Open Medicine 2015, 3: 2050312114568476. PMID: 26770763, PMCID: PMC4679226, DOI: 10.1177/2050312114568476.Peer-Reviewed Original ResearchCardiac autonomic neuropathyHeart rate ratioAdverse cardiac outcomesHigher pulse pressureAutonomic neuropathyType 2 diabetesCardiac outcomesNon-Black ethnicityHeart rate variabilityInsulin useAsymptomatic individualsPulse pressureCardiac diseaseHeart rateRate ratioGreater systolic blood pressure decreasePower spectral analysisSystolic blood pressure decreaseRate variabilityAsymptomatic Diabetics (DIAD) studyAsymptomatic type 2Composite clinical outcomeHigher glycated hemoglobinPoor cardiac outcomesPoor cardiovascular outcomes
2011
85% of maximal age-predicted heart rate is not a valid endpoint for exercise treadmill testing
Jain M, Nkonde C, Lin BA, Walker A, Wackers FJ. 85% of maximal age-predicted heart rate is not a valid endpoint for exercise treadmill testing. Journal Of Nuclear Cardiology 2011, 18: 1026-1035. PMID: 21922347, DOI: 10.1007/s12350-011-9454-0.Peer-Reviewed Original ResearchConceptsMaximal age-predicted heart rateAge-predicted heart rateInducible ischemiaPeak exerciseExercise testingPositive ECGHeart rateExercise endpointPositive exercise ECGExercise treadmill testingRegistry patientsProspective registryExercise capacityRetrospective cohortTreadmill testingPatient cohortExercise ECGValid endpointPatientsMore womenEndpointIschemiaClinical laboratoriesECGCohort
1998
Effects of Mental Stress on Left Ventricular and Peripheral Vascular Performance in Patients With Coronary Artery Disease
Jain D, Shaker M, Burg M, Wackers F, Soufer R, Zaret B. Effects of Mental Stress on Left Ventricular and Peripheral Vascular Performance in Patients With Coronary Artery Disease. Journal Of The American College Of Cardiology 1998, 31: 1314-1322. PMID: 9581726, DOI: 10.1016/s0735-1097(98)00092-8.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionPeripheral vascular resistanceCoronary artery diseaseRate-pressure productStress-induced fallSystolic blood pressureArtery diseaseBlood pressureCardiac outputHeart rateMental stressGroup IHemodynamic variablesAnger recallGroup IIMental stressorsEnd-systolic ventricular elastanceMental stress-induced changesSemisupine bicycle exerciseGroup II patientsComparable increaseDiastolic blood pressureVentricular ejection fractionExercise-induced changesVascular resistance
1995
962-67 Dobutamine Stress has a Limited Value for Enhancing Flow Heterogeneity in the Presence of a Moderate Stenosis When Used in Conjunction with Tc99m-Sestamibi Imaging
Yun J, Wu J, Heller E, Deckelbaum L, Dione D, Liu Y, Wackers F, Sinusas A. 962-67 Dobutamine Stress has a Limited Value for Enhancing Flow Heterogeneity in the Presence of a Moderate Stenosis When Used in Conjunction with Tc99m-Sestamibi Imaging. Journal Of The American College Of Cardiology 1995, 25: 217a. DOI: 10.1016/0735-1097(95)92360-h.Peer-Reviewed Original ResearchMB activityModerate stenosisDOB stressMean aortic pressureOpen-chest dogsSPECT perfusion imagingLCX stenosisProximal LCXPeak dobutamineAortic pressureDobutamine stressMB injectionChest dogsHeart rateNonischemicStenosisDobutamineIschemic regionPerfusion imagingFlow probeRadiolabeled microspheresFlow deficitsMicrosphere flowLimited valueBaseline
1994
Fetal Responses to Maternal Exercise: Effect on Fetal Breathing and Body Movement
Winn H, Hess O, Goldstein I, Wackers F, Hobbins J. Fetal Responses to Maternal Exercise: Effect on Fetal Breathing and Body Movement. American Journal Of Perinatology 1994, 11: 263-266. PMID: 7945619, DOI: 10.1055/s-2007-994588.Peer-Reviewed Original ResearchConceptsFetal body movementsMaternal heart rateMaternal exerciseFetal breathingHeart rateAge-predicted maximal heart rateMaximal heart rateReal-time ultrasonographyStandardized exercise testBlood pressureBruce protocolFetal responseGestational ageHealthy patientsExercise testFetal activityBody movementsSignificant decreaseBreathingTotal durationPatientsSignificant increaseExercisePregnancyUltrasonography
1988
Oral Terbutaline Augments Cardiac Performance in Chronic Obstructive Pulmonary Disease
Chan C, Loke J, Snyder P, Wackers F, Mattera J, Matthay R. Oral Terbutaline Augments Cardiac Performance in Chronic Obstructive Pulmonary Disease. The American Journal Of The Medical Sciences 1988, 296: 33-38. PMID: 3044105, DOI: 10.1097/00000441-198807000-00007.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseVentricular ejection fractionSubmaximal steady-state exerciseOral terbutalineSteady-state exerciseEjection fractionPulmonary diseaseSevere chronic obstructive pulmonary diseaseLeft ventricular ejection fractionFirst-pass radionuclide angiographySystolic pump performancePlacebo-controlled trialState exerciseExpiratory volumeBlood pressureCardiopulmonary effectsPlacebo dayHemodynamic measurementsVital capacityRadionuclide angiographyCardiac functionSubmaximal exerciseCardiac performanceHeart rate