2017
The Significance of Upfront Knowledge of N2 Disease in Non‐small Cell Lung Cancer
Thomas DC, Arnold BN, Rosen JE, Salazar MC, Detterbeck FC, Blasberg JD, Boffa DJ, Kim AW. The Significance of Upfront Knowledge of N2 Disease in Non‐small Cell Lung Cancer. World Journal Of Surgery 2017, 42: 161-171. PMID: 28799084, DOI: 10.1007/s00268-017-4165-6.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerUnsuspected N2 diseaseIII-N2 non-small cell lung cancerN2 diseaseCell lung cancerSurgical resectionAdjuvant chemotherapyAdjuvant therapyOverall survivalPathologic stageLung cancerMultivariate analysisCurative-intent surgical resectionStage IIIA NSCLCHigher comorbidity scoreNational Cancer DatabaseIndependent risk factorKaplan-Meier analysisCN2 diseaseIIIA NSCLCComorbidity scoreCancer DatabaseRisk factorsRetrospective analysisRadiation therapy
2016
Video-assisted thoracic surgery and open chest surgery in lung cancer treatment: present and future
Detterbeck F, Molins L. Video-assisted thoracic surgery and open chest surgery in lung cancer treatment: present and future. Journal Of Visualized Surgery 2016, 2: 173-173. PMID: 29078558, PMCID: PMC5637756, DOI: 10.21037/jovs.2016.11.03.Peer-Reviewed Original ResearchVideo-assisted thoracic surgeryThoracic surgerySimilar long-term survivalEarly-stage lung cancerShorter hospital stayStage lung cancerLung cancer treatmentOpen chest surgeryLong-term survivalHospital staySurgical resectionOpen surgerySurgical approachLung cancerOpen techniqueChest surgeryEffective treatmentLimited incisionTerm survivalSurgeryOpen approachParticular tumorCancer treatmentTreatmentResectionDefining outcomes of patients with clinical stage I small cell lung cancer upstaged at surgery
Thomas DC, Arnold BN, Rosen JE, Salazar MC, Blasberg JD, Detterbeck FC, Boffa DJ, Kim AW. Defining outcomes of patients with clinical stage I small cell lung cancer upstaged at surgery. Lung Cancer 2016, 103: 75-81. PMID: 28024700, DOI: 10.1016/j.lungcan.2016.11.016.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCarcinoma, Non-Small-Cell LungChemotherapy, AdjuvantCombined Modality TherapyDatabases, FactualFemaleGuidelines as TopicHumansLung NeoplasmsLymphatic MetastasisMaleMiddle AgedNeoplasm StagingOutcome Assessment, Health CarePneumonectomyPostoperative PeriodRadiotherapySmall Cell Lung CarcinomaSurvival AnalysisConceptsStage I small cell lung cancerClinical stage ISmall cell lung cancerCell lung cancerAdjuvant chemotherapySurgical resectionPathologic upstagingStage IRadiation therapyNodal diseaseLung cancerPositive lymph node involvementNational Cancer DatabaseOutcomes of patientsLymph node involvementProportion of patientsCurative intentNodal upstagingSCLC patientsUpstaged patientsAdjuvant therapyNode involvementIndependent predictorsInferior survivalT descriptorThymic Carcinoma Management Patterns among International Thymic Malignancy Interest Group (ITMIG) Physicians with Consensus from the Thymic Carcinoma Working Group
Shepherd A, Riely G, Detterbeck F, Simone CB, Ahmad U, Huang J, Korst R, Rajan A, Rimner A. Thymic Carcinoma Management Patterns among International Thymic Malignancy Interest Group (ITMIG) Physicians with Consensus from the Thymic Carcinoma Working Group. Journal Of Thoracic Oncology 2016, 12: 745-751. PMID: 27876674, PMCID: PMC5545114, DOI: 10.1016/j.jtho.2016.11.2219.Peer-Reviewed Original ResearchConceptsInternational Thymic Malignancy Interest GroupThymic carcinomaAreas of controversyResectable diseaseMultimodality therapyClinical practiceFirst-line chemotherapy regimenDefinitive surgical resectionRare epithelial malignancyManagement of patientsCurrent clinical practiceFit patientsAdjuvant therapyChemotherapy regimenSurgical resectionThymic malignanciesHistologic confirmationTreatment courseTreatment strategiesEpithelial malignanciesGreat vesselsMultidisciplinary discussionGroup physiciansWorking GroupCarcinomaTiming of Surgery after Neoadjuvant Chemoradiation in Locally Advanced Non–Small Cell Lung Cancer
Gao SJ, Corso CD, Wang EH, Blasberg JD, Detterbeck FC, Boffa DJ, Decker RH, Kim AW. Timing of Surgery after Neoadjuvant Chemoradiation in Locally Advanced Non–Small Cell Lung Cancer. Journal Of Thoracic Oncology 2016, 12: 314-322. PMID: 27720827, DOI: 10.1016/j.jtho.2016.09.122.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCarcinoma, Large CellCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellChemoradiotherapy, AdjuvantCombined Modality TherapyFemaleFollow-Up StudiesHumansLung NeoplasmsMaleMiddle AgedNeoadjuvant TherapyNeoplasm StagingPneumonectomyPrognosisRetrospective StudiesSurvival RateTime FactorsConceptsNational Cancer Data BaseNeoadjuvant chemoradiationTiming of surgeryOverall survivalAdvanced non-small cell lung cancerNon-small cell lung cancerStage IIIA-N2 NSCLCStage IIIA NSCLCKaplan-Meier methodOverall survival rateSubset of patientsCell lung cancerLog-rank testMultivariate survival analysisProportional hazards modelIIIA NSCLCN2 NSCLCNeoadjuvant therapyTrimodality therapySurgical resectionClinical stageRetrospective studyLung cancerHazards modelSurvival rateThe Natural History of Operable Non-Small Cell Lung Cancer in the National Cancer Database
Rosen JE, Keshava HB, Yao X, Kim AW, Detterbeck FC, Boffa DJ. The Natural History of Operable Non-Small Cell Lung Cancer in the National Cancer Database. The Annals Of Thoracic Surgery 2016, 101: 1850-1855. PMID: 27041452, DOI: 10.1016/j.athoracsur.2016.01.077.Peer-Reviewed Original ResearchConceptsOperable non-small cell lung cancerNon-small cell lung cancerNational Cancer DatabaseUntreated NSCLC patientsClinical stage ICell lung cancerNSCLC patientsNatural historyStage ILung cancerCancer DatabaseUntreated non-small cell lung cancerIIIA non-small cell lung cancerMultivariable Cox regression modelsLarge cell histologyNatural history cohortOperable NSCLC patientsCox regression modelMedian survivalUntreated patientsCell histologyMeier estimatesSurgical resectionClinical stageSquamous cellsAdjuvant Chemotherapy for T3 Non–Small Cell Lung Cancer with Additional Tumor Nodules in the Same Lobe
Salazar MC, Rosen JE, Arnold BN, Thomas DC, Kim AW, Detterbeck FC, Blasberg JD, Boffa DJ. Adjuvant Chemotherapy for T3 Non–Small Cell Lung Cancer with Additional Tumor Nodules in the Same Lobe. Journal Of Thoracic Oncology 2016, 11: 1090-1100. PMID: 27013407, DOI: 10.1016/j.jtho.2016.03.009.Peer-Reviewed Original ResearchConceptsAdditional tumor nodulesAdjuvant chemotherapyT3 tumorsSame lobeTumor nodulesPostoperative chemotherapyOverall survivalSurgical resectionSurvival advantageNon-small cell lung cancerNational Cancer Data BaseNon-small cell lungAdditional pulmonary nodulesAdjuvant chemotherapy subgroupSurvival of patientsCell lung cancerSeparate tumor nodulesChemotherapy subgroupPrimary outcomeCell lungLung cancerChemotherapyCox modelRelative survivalPatients
2015
Evaluating the fate of patients who undergo resections of very large, node-negative lung cancers using the National Cancer DataBase
Liu J, Hancock JG, Moreno AC, Wang Z, Boffa DJ, Detterbeck FC, Kim AW. Evaluating the fate of patients who undergo resections of very large, node-negative lung cancers using the National Cancer DataBase. European Journal Of Cardio-Thoracic Surgery 2015, 49: 596-601. PMID: 25890936, DOI: 10.1093/ejcts/ezv139.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellChemoradiotherapy, AdjuvantDatabases, FactualFemaleFollow-Up StudiesHumansLung NeoplasmsLymph NodesMaleMiddle AgedNeoadjuvant TherapyNeoplasm StagingPneumonectomyRetrospective StudiesSurvival AnalysisTreatment OutcomeTumor BurdenUnited StatesConceptsPostoperative radiation therapyNational Cancer DatabaseNeoadjuvant chemoradiation therapyAdjuvant chemoradiation therapyChemoradiation therapyAdjuvant chemotherapyOverall survivalSurgical therapyLung cancerCancer DatabaseNode-negative lung cancerImproved OS relativeLymph node involvementKaplan-Meier methodCell lung cancerCox regression modelFate of patientsLog-rank testDifferent treatment modalitiesOS relativeNode involvementMetastatic diseaseSurgical resectionLymph nodesOS ratesBolstering the Case for Lobectomy in Stages I, II, and IIIA Small-Cell Lung Cancer Using the National Cancer Data Base
Combs SE, Hancock JG, Boffa DJ, Decker RH, Detterbeck FC, Kim AW. Bolstering the Case for Lobectomy in Stages I, II, and IIIA Small-Cell Lung Cancer Using the National Cancer Data Base. Journal Of Thoracic Oncology 2015, 10: 316-323. PMID: 25319182, DOI: 10.1097/jto.0000000000000402.Peer-Reviewed Original ResearchConceptsSmall cell lung cancerNational Cancer Data BaseSurgical resectionStage ISCLC patientsSublobar resectionOverall survivalLung cancerIIIA small cell lung cancerFive-year overall survivalAddition of surgeryClinical stage IPatient underwent surgeryPrimary surgical resectionKaplan-Meier methodLikelihood of deathCurative intentComorbidity scoreUnderwent surgeryChemoradiation therapyHazard ratioMetastatic diseaseMultimodality treatmentSelect patientsTreatment regimen
2014
Predictors of Mortality After Surgical Management of Lung Cancer in the National Cancer Database
Rosen JE, Hancock JG, Kim AW, Detterbeck FC, Boffa DJ. Predictors of Mortality After Surgical Management of Lung Cancer in the National Cancer Database. The Annals Of Thoracic Surgery 2014, 98: 1953-1960. PMID: 25443003, DOI: 10.1016/j.athoracsur.2014.07.007.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerNational Cancer DatabaseLobectomy/bilobectomyAdverse eventsSurgical resectionMultivariable analysisMale sexFacility volumeLung cancerCancer DatabaseLung cancer surgeryPredictors of mortalityRight-sided tumorsDay of surgeryCell lung cancerStandard of careExtended lengthLarge cancer registryPerioperative outcomesPrimary endpointNSCLC patientsSurgical complicationsWedge resectionSurgical treatmentCancer Registry
2013
Thymoma: current diagnosis and treatment.
Detterbeck FC, Zeeshan A. Thymoma: current diagnosis and treatment. Chinese Medical Journal 2013, 126: 2186-91. PMID: 23769581, DOI: 10.3760/cma.j.issn.0366-6999.20130177.Peer-Reviewed Original ResearchConceptsComplete resectionInternational Thymic Malignancy Interest GroupMasaoka-Koga classificationMainstay of treatmentMajor prognostic factorAnterior mediastinal tumorTreatment of thymomaEarly-stage thymomaRare malignant tumorCore needle biopsyStandard diagnostic modalityFine-needle aspirationFormal systematic reviewMajor blood vesselsIVA tumorsPreoperative chemotherapyPrimary surgeryPostoperative radiationPrognostic factorsSurgical resectionThymic malignanciesMediastinal tumorMyasthenia gravisThymoma resectionIntravenous contrastSpecial Treatment Issues in Non-small Cell Lung Cancer Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
Kozower BD, Larner JM, Detterbeck FC, Jones DR. Special Treatment Issues in Non-small Cell Lung Cancer Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. CHEST Journal 2013, 143: e369s-e399s. PMID: 23649447, DOI: 10.1378/chest.12-2362.Peer-Reviewed Original ResearchConceptsSecond primary lung cancerChest wall involvementPrimary lung cancerLung cancerSurgical resectionPancoast tumorWall involvementAmerican CollegeChest Physicians Evidence-Based Clinical Practice GuidelinesMetachronous second primary lung cancerEvidence-based clinical practice guidelinesNon-small cell lung cancer diagnosisNon-small cell lung cancerLonger disease-free intervalCell lung cancer diagnosisIpsilateral different lobeMediastinal node involvementN2 nodal diseaseSpecial clinical casesThoracic Oncology NetworkAggressive surgical approachDisease-free intervalPrimary surgical resectionExperienced multidisciplinary teamLarge prospective studiesUse of New Treatment Modalities for Non-small Cell Lung Cancer Care in the Medicare Population
Vest MT, Herrin J, Soulos PR, Decker RH, Tanoue L, Michaud G, Kim AW, Detterbeck F, Morgensztern D, Gross CP. Use of New Treatment Modalities for Non-small Cell Lung Cancer Care in the Medicare Population. CHEST Journal 2013, 143: 429-435. PMID: 23187634, PMCID: PMC3566996, DOI: 10.1378/chest.12-1149.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerStage I non-small cell lung cancerVideo-assisted thoracoscopic surgeryProportion of patientsOlder patientsCancer careNon-small cell lung cancer careEarly-stage non-small cell lung cancerStage non-small cell lung cancerEnd Results-Medicare databaseLung cancer careCell lung cancerCurative local therapyNew treatment modalitiesOverall useNew surgical techniqueType of treatmentNew radiation modalitiesRadiation therapy modalitiesSurgical resectionCurative therapyLocal therapyMore patientsThoracoscopic surgeryMean age
2012
Characteristics Associated With the Use of Nonanatomic Resections Among Medicare Patients Undergoing Resections of Early-Stage Lung Cancer
Kim AW, Detterbeck FC, Boffa DJ, Decker RH, Soulos PR, Cramer LD, Gross CP. Characteristics Associated With the Use of Nonanatomic Resections Among Medicare Patients Undergoing Resections of Early-Stage Lung Cancer. The Annals Of Thoracic Surgery 2012, 94: 895-901. PMID: 22835558, PMCID: PMC3501201, DOI: 10.1016/j.athoracsur.2012.04.091.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overCarcinoma, Non-Small-Cell LungConfidence IntervalsDisease-Free SurvivalEthnicityFemaleHumansLogistic ModelsLungLung NeoplasmsMaleMedicareMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingOdds RatioPneumonectomyPostoperative ComplicationsPrognosisRetrospective StudiesRisk AssessmentSEER ProgramSex DistributionSurvival AnalysisUnited StatesConceptsChronic obstructive pulmonary diseaseNonanatomic resectionStage I NSCLCSurgical resectionSurgical approachLung cancerNational Cancer Institute's SurveillanceEarly-stage lung cancerPatients 67 yearsPrimary tumor statusObstructive pulmonary diseaseCell lung cancerHospital factorsLung resectionWedge resectionClinical factorsPulmonary diseaseMultivariable analysisTumor sizeLarge tumorsHospital characteristicsTumor statusMedicare patientsResectionPatients
2010
Evaluation and Treatment of Stage I and II Thymoma
Detterbeck FC. Evaluation and Treatment of Stage I and II Thymoma. Journal Of Thoracic Oncology 2010, 5: s318-s322. PMID: 20859126, DOI: 10.1097/jto.0b013e3181f20dab.Peer-Reviewed Original Research
2009
Impact of Preoperative Chemotherapy on Pulmonary Function Tests in Resectable Early-Stage Non-small Cell Lung Cancer
Rivera MP, Detterbeck FC, Socinski MA, Moore DT, Edelman MJ, Jahan TM, Ansari RH, Luketich JD, Peng G, Monberg M, Obasaju CK, Gralla RJ. Impact of Preoperative Chemotherapy on Pulmonary Function Tests in Resectable Early-Stage Non-small Cell Lung Cancer. CHEST Journal 2009, 135: 1588-1595. PMID: 19188545, DOI: 10.1378/chest.08-1430.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCarcinoma, Non-Small-Cell LungChemotherapy, AdjuvantCisplatinConfidence IntervalsDeoxycytidineDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesGemcitabineHumansLung NeoplasmsMaleMaximum Tolerated DoseMiddle AgedNeoadjuvant TherapyNeoplasm StagingPaclitaxelPneumonectomyPreoperative CareProbabilityRespiratory Function TestsRisk AssessmentSurvival AnalysisConceptsNon-small cell lung cancerCell lung cancerSurgical resectionLung cancerPulmonary toxicityResectable early stage non-small cell lung cancerEarly-stage non-small cell lung cancerRandomized phase 2 trialPulmonary function test resultsSecondary end pointsCombination of gemcitabinePhase 2 trialPulmonary function testsGemcitabine-based chemotherapyFunction test resultsTotal lung capacityEligible patientsNonplatinum regimensDyspnea scoreInterstitial pneumonitisPreoperative chemotherapyFunction testsSmoking statusClinical symptomsPreoperative setting
2003
Multifocal right atrial myxoma and pulmonary embolism
Parsons AM, Detterbeck FC. Multifocal right atrial myxoma and pulmonary embolism. The Annals Of Thoracic Surgery 2003, 75: 1323-1324. PMID: 12683591, DOI: 10.1016/s0003-4975(02)04563-0.Peer-Reviewed Original ResearchConceptsPulmonary embolismAtrial myxomaBilateral pulmonary embolismRight heart failureRight atrial myxomaEvidence of recurrencePulmonary arterial flowSurgical resectionHeart failureCardiac myxomaComplete occlusionArterial flowComplete recoveryMyxomaFamilial settingEmbolismRecurrenceResectionDiseaseOcclusionWomenSpecial Treatment Issues*
Detterbeck FC, Jones DR, Kernstine KH, Naunheim KS. Special Treatment Issues*. CHEST Journal 2003, 123: 244s-258s. PMID: 12527583, DOI: 10.1378/chest.123.1_suppl.244s.Peer-Reviewed Original ResearchConceptsMetachronous multiple primary lung cancerPrimary lung cancerSecond primary lung cancerLung cancerPancoast tumorPrimary tumorSame lobeNon-small cell lung cancerMultiple primary lung cancersLung cancer guidelinesMediastinal node involvementCell lung cancerNode involvementT4 tumorsMetachronous presentationMetastatic diseasePulmonary metastasesSolitary metastasisSurgical resectionCancer guidelinesSuch patientsBetter prognosisSatellite nodulesMultimodality approachAdrenal glandGemcitabine-Based Combinations as Preoperative Therapy in Resectable Non–Small-Cell Lung Cancer
Socinski MA, Rivera MP, Detterbeck FC. Gemcitabine-Based Combinations as Preoperative Therapy in Resectable Non–Small-Cell Lung Cancer. Clinical Lung Cancer 2003, 4: s50-s55. PMID: 14720337, DOI: 10.3816/clc.2003.s.004.Peer-Reviewed Original ResearchGemcitabine-containing regimensPhase III trialsStage III NSCLCComplete surgical resectionPreoperative therapyIII trialsSurgical resectionInduction therapyLung cancerResectable non-small cell lung cancerNon-small cell lung cancerDominant recurrence patternGemcitabine-based combinationsSystemic micrometastatic diseaseCisplatin/gemcitabinePhase II trialMajority of patientsMinority of patientsCell lung cancerOverall response rateStandard of careAdjuvant chemotherapyAdvanced NSCLCII trialStage IB