2018
Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism
Heipertz EL, Harper J, Lopez CA, Fikrig E, Hughes ME, Walker WE. Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism. The Journal Of Immunology 2018, 201: ji1701677. PMID: 29760192, PMCID: PMC9351006, DOI: 10.4049/jimmunol.1701677.Peer-Reviewed Original ResearchConceptsImmune cellsZT 19C57BL/6 miceWorse outcomesTLR2 agonist lipoteichoic acidCircadian rhythmTLR2 knockout miceFemale C57BL/6 miceMale C57BL/6 miceSeverity of sepsisBone marrow chimerasTLR2-dependent mechanismIL-6 productionTLR2-DependentSepsis severityCecal ligationSepsis phenotypesSepsisC57BL/6 cellsSimilar outcomesMiceMouse cecumLipoteichoic acidMurine macrophagesCLP
2009
Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy
Demento SL, Eisenbarth SC, Foellmer HG, Platt C, Caplan MJ, Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell RA, Fahmy TM. Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine 2009, 27: 3013-3021. PMID: 19428913, PMCID: PMC2695996, DOI: 10.1016/j.vaccine.2009.03.034.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAnimalsAntibody FormationCarrier ProteinsCD8-Positive T-LymphocytesDendritic CellsLactic AcidLipopolysaccharidesMiceMice, Inbred C57BLNanoparticlesNLR Family, Pyrin Domain-Containing 3 ProteinPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerVaccinationViral Envelope ProteinsWest Nile FeverWest Nile Virus VaccinesConceptsPattern recognition receptorsToll-like receptorsInflammasome activationInnate immune system activationEffective adaptive immune responseIntracellular pattern recognition receptorsAntigen-presenting cellsAdaptive immune responsesWest Nile encephalitisImmune system activationInnate immune pathwaysWild-type macrophagesDendritic cellsCellular immunityVaccination approachesVaccine efficacyIL-1betaNLRP3 inflammasomeAdjuvant systemImmune responsePotent new approachMurine modelInflammasome activitySystem activationImmune pathways
1992
Nonspecific Proliferative Responses of Murine Lymphocytes to Borrelia burgdorferi Antigens
de Souza M, Fikrig E, Smith A, Flavell R, Barthold SW. Nonspecific Proliferative Responses of Murine Lymphocytes to Borrelia burgdorferi Antigens. The Journal Of Infectious Diseases 1992, 165: 471-478. PMID: 1531672, DOI: 10.1093/infdis/165.3.471.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial ProteinsBacterial VaccinesBorrelia burgdorferi GroupDose-Response Relationship, ImmunologicFlow CytometryImmunoglobulin GImmunoglobulin MLipopolysaccharidesLipoproteinsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C3HRecombinant ProteinsSpecific Pathogen-Free OrganismsConceptsBorrelia burgdorferi antigensNaive splenocytesNonspecific proliferationProliferative responseB. burgdorferiC3H/HeNCrlBR miceRecombinant outer surface proteinB cell-enriched fractionC3H/HeJ miceNonspecific proliferative responseAntigen-specific proliferationStrains of miceCell-enriched fractionB. burgdorferi spirochetesIgG synthesisHeJ miceB cellsMitogenic effectOuter surface proteinsMurine lymphocytesLyme borreliosisMiceSplenocytesBurgdorferiAntigen