Genomic landscape of de novo stage IV breast cancer.
Garrido-Castro A, Spurr L, Hughes M, Li Y, Cherniack A, Bychkovsky B, Barroso-Sousa R, Di Lascio S, Files J, Kumari P, Cerami E, Krop I, MacConaill L, Lindeman N, Rollins B, Johnson B, Wagle N, Winer E, Dillon D, Lin N. Genomic landscape of de novo stage IV breast cancer. Journal Of Clinical Oncology 2019, 37: 1022-1022. DOI: 10.1200/jco.2019.37.15_suppl.1022.Peer-Reviewed Original ResearchDe novo stage IV breast cancerRecurrent metastatic breast cancerStage IV breast cancerBreast cancerMetastatic tumorsMHC class II expressionMetastatic breast cancerPoor overall survivalClass II expressionFisher's exact testEpithelial-mesenchymal transitionPrimary TNBCCopy number variationsOverall survivalMetastatic sitesCCND1 amplificationImmune escapePotential resistance mechanismsDistinct genomic profilesMetastatic driversMetastatic samplesTreatment selectionExact testMetastatic potentialGenomic profiling