Patient-reported outcomes from the phase III IMpassion130 trial of atezolizumab plus nab-paclitaxel in metastatic triple-negative breast cancer
Adams S, Diéras V, Barrios CH, Winer EP, Schneeweiss A, Iwata H, Loi S, Patel S, Henschel V, Chui SY, Rugo HS, Emens LA, Schmid P. Patient-reported outcomes from the phase III IMpassion130 trial of atezolizumab plus nab-paclitaxel in metastatic triple-negative breast cancer. Annals Of Oncology 2020, 31: 582-589. PMID: 32178964, DOI: 10.1016/j.annonc.2020.02.003.Peer-Reviewed Original ResearchConceptsMetastatic triple-negative breast cancerPatient-reported outcomesTriple-negative breast cancerFirst-line treatmentHealth-related qualityNab-paclitaxelPD-L1Treatment symptomsBreast cancerBaseline scoresDay 1Progression-free survival benefitPatients' health-related qualityEnd pointBreast cancer moduleExploratory end pointsSecondary end pointsTreatment-related symptomsEnd of treatmentKey treatment goalMean baseline scoreCourse of treatmentITT patientsMeaningful worseningMTNBC patients