2016
Evaluation of the Effect of Diagnostic Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules
Noureldine S, Najafian A, Han P, Olson M, Genther D, Schneider E, Prescott J, Agrawal N, Mathur A, Zeiger M, Tufano R. Evaluation of the Effect of Diagnostic Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules. JAMA Otolaryngology - Head & Neck Surgery 2016, 142: 676-82. PMID: 27196108, DOI: 10.1001/jamaoto.2016.0850.Peer-Reviewed Original ResearchConceptsSurgical decision-making processMolecular testingSurgical consultationThyroid nodulesDiagnostic molecular testingEvidence of overtreatmentPertinent treatment optionsSurgical management algorithmRisk of malignancySurgical decision makingSurgical management planRadiological resultsStudy cohortSurgical managementTreatment algorithmProspective studyMean ageTreatment optionsMAIN OUTCOMEPatientsBethesda SystemHistopathology diagnosisControl groupCytopathology classificationHistopathology analysis
2014
Development of a duplex-derived velocity risk prediction model of disease progression in patients with moderate asymptomatic carotid artery stenosis
Hicks CW, Canner JK, Arhuidese I, Glebova NO, Schneider E, Qazi U, Perler B, Malas MB. Development of a duplex-derived velocity risk prediction model of disease progression in patients with moderate asymptomatic carotid artery stenosis. Journal Of Vascular Surgery 2014, 60: 1585-1592. PMID: 25238724, DOI: 10.1016/j.jvs.2014.08.056.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArea Under CurveAsymptomatic DiseasesBlood Flow VelocityCarotid Artery, CommonCarotid Artery, InternalCarotid StenosisChi-Square DistributionDecision Support TechniquesDisease ProgressionFemaleHumansMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProportional Hazards ModelsRegional Blood FlowRetrospective StudiesRisk AssessmentRisk FactorsROC CurveTime FactorsUltrasonography, Doppler, DuplexConceptsAsymptomatic carotid artery stenosisICA/CCA ratioCarotid artery stenosisInternal carotid arteryDisease progressionEnd-diastolic velocityPeak systolic velocityRisk prediction modelCCA ratioArtery stenosisSystolic velocityRisk factorsInitial peak systolic velocityProportional hazards regression modelsHigh-risk patientsRisk of progressionRisk-stratify patientsHazards regression modelsSignificant independent predictorsICA/CCACharacteristic curve analysisClinical prediction modelCarotid artery ratioIndependent predictorsDuplex imagingThe Impact of Molecular Testing on the Surgical Management of Patients with Thyroid Nodules
Aragon Han P, Olson M, Fazeli R, Prescott J, Pai S, Schneider E, Tufano R, Zeiger M. The Impact of Molecular Testing on the Surgical Management of Patients with Thyroid Nodules. Annals Of Surgical Oncology 2014, 21: 1862-1869. PMID: 24522987, DOI: 10.1245/s10434-014-3508-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBiopsy, Fine-NeedleDecision Support TechniquesDNA Mutational AnalysisFemaleGene Expression ProfilingGTP PhosphohydrolasesHumansMaleMembrane ProteinsMiddle AgedPredictive Value of TestsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-retRetrospective StudiesThyroid GlandThyroid NoduleConceptsSurgical managementPreoperative molecular testingMolecular testingThyroid nodulesRET/PTC translocationsPathology analysisMolecular testsSurgical management changesSurgical management decisionsTertiary care centerMajority of patientsSurgical management algorithmJohns Hopkins HospitalPostoperative pathology analysisGene expression classifierUnderwent surgerySurgical consultationThyroid surgeryMethodsClinical informationThyroid surgeonsCare centerFNA diagnosisPatientsSurgical practiceSurgical planning