2016
Evaluation of the Effect of Diagnostic Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules
Noureldine S, Najafian A, Han P, Olson M, Genther D, Schneider E, Prescott J, Agrawal N, Mathur A, Zeiger M, Tufano R. Evaluation of the Effect of Diagnostic Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules. JAMA Otolaryngology - Head & Neck Surgery 2016, 142: 676-82. PMID: 27196108, DOI: 10.1001/jamaoto.2016.0850.Peer-Reviewed Original ResearchConceptsSurgical decision-making processMolecular testingSurgical consultationThyroid nodulesDiagnostic molecular testingEvidence of overtreatmentPertinent treatment optionsSurgical management algorithmRisk of malignancySurgical decision makingSurgical management planRadiological resultsStudy cohortSurgical managementTreatment algorithmProspective studyMean ageTreatment optionsMAIN OUTCOMEPatientsBethesda SystemHistopathology diagnosisControl groupCytopathology classificationHistopathology analysis
2015
Conventional smears versus liquid-based preparations for thyroid fine-needle aspirates: a systematic review and meta-analysis
Nagarajan N, Najafian A, Schneider E, Zeiger M, Olson M. Conventional smears versus liquid-based preparations for thyroid fine-needle aspirates: a systematic review and meta-analysis. Journal Of The American Society Of Cytopathology 2015, 4: 253-260. PMID: 31051762, DOI: 10.1016/j.jasc.2015.02.003.Peer-Reviewed Original ResearchFine-needle aspirationLiquid-based preparationsThyroid fine-needle aspirationConventional smearsLower riskInadequate smearsConsecutive thyroid fine-needle aspirationsTitle/abstract screeningDouble data extractionRisk of biasThyroid fine-needle aspiratesFine needle aspiratesFollowing outcomesStatistical heterogeneityObservational studySystematic reviewThyroid nodulesAbstract screeningSmearsLack of consensusData extractionRelevant studiesFurther studiesFull textRiskHow Do Liquid-Based Preparations of Thyroid Fine-Needle Aspiration Compare with Conventional Smears? An Analysis of 5475 Specimens
Nagarajan N, Schneider EB, Ali SZ, Zeiger MA, Olson MT. How Do Liquid-Based Preparations of Thyroid Fine-Needle Aspiration Compare with Conventional Smears? An Analysis of 5475 Specimens. Thyroid 2015, 25: 308-313. PMID: 25420135, DOI: 10.1089/thy.2014.0394.Peer-Reviewed Original ResearchConceptsFine-needle aspirationLiquid-based preparationsLBP casesConventional smearsBenign diagnosisThyroid nodulesMalignant diagnosisHistology diagnosisAspirated materialClinical databaseSuspicious categoryCS casesInitial evaluationInadequate samplesDiagnosisNodule sizePatientsSecond reviewDiagnostic frequencySmearsInadequate rateHigher proportionLower proportionPivotal roleNodules
2014
The Impact of Molecular Testing on the Surgical Management of Patients with Thyroid Nodules
Aragon Han P, Olson M, Fazeli R, Prescott J, Pai S, Schneider E, Tufano R, Zeiger M. The Impact of Molecular Testing on the Surgical Management of Patients with Thyroid Nodules. Annals Of Surgical Oncology 2014, 21: 1862-1869. PMID: 24522987, DOI: 10.1245/s10434-014-3508-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBiopsy, Fine-NeedleDecision Support TechniquesDNA Mutational AnalysisFemaleGene Expression ProfilingGTP PhosphohydrolasesHumansMaleMembrane ProteinsMiddle AgedPredictive Value of TestsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-retRetrospective StudiesThyroid GlandThyroid NoduleConceptsSurgical managementPreoperative molecular testingMolecular testingThyroid nodulesRET/PTC translocationsPathology analysisMolecular testsSurgical management changesSurgical management decisionsTertiary care centerMajority of patientsSurgical management algorithmJohns Hopkins HospitalPostoperative pathology analysisGene expression classifierUnderwent surgerySurgical consultationThyroid surgeryMethodsClinical informationThyroid surgeonsCare centerFNA diagnosisPatientsSurgical practiceSurgical planning
2011
Predictive factors of malignancy in pediatric thyroid nodules
Roy R, Kouniavsky G, Schneider E, Allendorf JD, Chabot JA, Logerfo P, Dackiw AP, Colombani P, Zeiger MA, Lee JA. Predictive factors of malignancy in pediatric thyroid nodules. Surgery 2011, 150: 1228-1233. PMID: 22136845, DOI: 10.1016/j.surg.2011.09.023.Peer-Reviewed Original ResearchConceptsFine-needle aspiration biopsy specimensPediatric thyroid nodulesPositive predictive valuePalpable lymphadenopathyThyroid nodulesThyroid cancerFamily historyPredictive valueAspiration biopsy specimensPediatric thyroidectomyFinal pathologyClinical factorsClinicopathologic factorsRetrospective reviewTertiary hospitalPredictive factorsHypoechoic lesionsBiopsy specimensHypoechoic nodulesIndeterminate lesionsMalignancyFNAB resultsLymphadenopathyGreater riskCancerThe role of preoperative neck ultrasounds to assess lymph nodes in patients with suspicious or indeterminate thyroid nodules
Roy R, Kouniavsky G, Venkat R, Felger E, Shiue Z, Schneider E, Zeiger M. The role of preoperative neck ultrasounds to assess lymph nodes in patients with suspicious or indeterminate thyroid nodules. Journal Of Surgical Oncology 2011, 105: 601-605. PMID: 22006435, PMCID: PMC3715078, DOI: 10.1002/jso.22115.Peer-Reviewed Original ResearchConceptsIndeterminate thyroid nodulesLymph nodesFormal lymph node dissectionThyroid nodulesPreoperative neck ultrasoundSuspicious lymph nodesLymph node dissectionSize of tumorCervical ultrasoundIndeterminate thyroid cytologyNode dissectionMetastatic diseaseNeck ultrasoundSurgical managementClinicopathological variablesPreoperative ultrasoundSurgical approachPreoperative neckUltrasound findingsMale genderMedical recordsOperative approachSurgical ultrasoundPatientsThyroid cytology