2023
An AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model
Charkoftaki G, Aalizadeh R, Santos-Neto A, Tan W, Davidson E, Nikolopoulou V, Wang Y, Thompson B, Furnary T, Chen Y, Wunder E, Coppi A, Schulz W, Iwasaki A, Pierce R, Cruz C, Desir G, Kaminski N, Farhadian S, Veselkov K, Datta R, Campbell M, Thomaidis N, Ko A, Thompson D, Vasiliou V. An AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model. Human Genomics 2023, 17: 80. PMID: 37641126, PMCID: PMC10463861, DOI: 10.1186/s40246-023-00521-4.Peer-Reviewed Original ResearchConceptsCOVID-19 patientsDisease severityViral outbreaksFuture viral outbreaksLength of hospitalizationIntensive care unitWorse disease prognosisLife-threatening illnessEffective medical interventionsCOVID-19Clinical decision treeGlucuronic acid metabolitesNew potential biomarkersHospitalization lengthCare unitComorbidity dataSerotonin levelsDisease progressionHealthy controlsPatient outcomesDisease prognosisPatient transferPatientsHealthcare resourcesPotential biomarkers
2022
Quantitative analysis of short-chain fatty acids in human plasma and serum by GC–MS
Yao L, Davidson E, Shaikh M, Forsyth C, Prenni J, Broeckling C. Quantitative analysis of short-chain fatty acids in human plasma and serum by GC–MS. Analytical And Bioanalytical Chemistry 2022, 414: 4391-4399. PMID: 35091760, DOI: 10.1007/s00216-021-03785-8.Peer-Reviewed Original Research
2021
Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function
Thompson B, Chen Y, Davidson EA, Garcia-Milian R, Golla JP, Apostolopoulos N, Orlicky DJ, Schey K, Thompson DC, Vasiliou V. Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function. The Ocular Surface 2021, 22: 190-203. PMID: 34425299, PMCID: PMC8560581, DOI: 10.1016/j.jtos.2021.08.010.Peer-Reviewed Original ResearchConceptsHEK293T cellsEye developmentGSH biosynthesisTransactivation activityPax6 functionReactive oxygen speciesSubsequent gene ontologyCell identity genesButhionine sulfoximineEpithelial cell identityRNA-seq analysisIngenuity Pathway AnalysisKey upstream regulatorIdentity genesCell identityGene OntologyRNA-seqImmune response genesBioinformatics analysisResponse genesGlutathione biosynthesisLens morphogenesisMolecular consequencesUpstream regulatorMicrophthalmia phenotype
2020
Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease
Thompson B, Davidson EA, Liu W, Nebert DW, Bruford EA, Zhao H, Dermitzakis ET, Thompson DC, Vasiliou V. Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease. Human Genetics 2020, 140: 381-400. PMID: 32728807, PMCID: PMC7939107, DOI: 10.1007/s00439-020-02212-9.Peer-Reviewed Original ResearchConceptsPax proteinsTranscript variant expressionHuman diseasesFunctional rolePax gene familyMyriad human diseasesPax family membersVariant expressionPotential functional significanceBox genesPax genesGene familyTranscriptional regulationCell identityLineage determinationOrgan developmentTranscription factorsMaster regulatorAdditional speciesCell differentiationDevelopmental diseasesGenomic updateFunctional significanceProteinGenes