Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice
Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG, Flavell RA. Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 13218-13223. PMID: 21788509, PMCID: PMC3156175, DOI: 10.1073/pnas.1109769108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, DifferentiationBone Marrow CellsCell LineageDNA-Binding ProteinsEpitopesHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHumansImmunity, HumoralInterleukin Receptor Common gamma SubunitMiceMice, Inbred BALB CMice, KnockoutMice, TransgenicReceptors, ImmunologicTransgenesConceptsSignal regulatory protein alphaBALB/c backgroundRegulatory protein alphaNSG miceImmune systemC backgroundHuman hematopoietic cellsNOD/SCID/Mouse strainsProtein alphaHuman cell engraftmentBALB/cUnique mouse strainHost immune functionHematopoietic cellsHuman immune systemHumanized miceSCID/Human hematopoietic stem cellsImmune responseHuman engraftmentSimilar miceImmune functionNewborn miceCell engraftmentEfficient differentiation and function of human macrophages in humanized CSF-1 mice
Rathinam C, Poueymirou WT, Rojas J, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rongvaux A, Eynon EE, Manz MG, Flavell RA. Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood 2011, 118: 3119-3128. PMID: 21791433, DOI: 10.1182/blood-2010-12-326926.Peer-Reviewed Original ResearchConceptsHuman monocytes/macrophagesMonocytes/macrophagesMice showHumanized mouse modelMyeloid cell biologyBALB/cHuman fetal liverHuman myeloid cellsHumanized micePeripheral bloodPeritoneal cavityMouse modelNewborn miceBone marrowMyeloid cellsHuman cytokinesHuman hematopoietic systemHuman macrophagesMiceValuable experimental modelExperimental modelFetal liverProgenitor cells