Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung
Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG, Flavell RA. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 2390-2395. PMID: 21262803, PMCID: PMC3038773, DOI: 10.1073/pnas.1019682108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCord Blood Stem Cell TransplantationGene Knock-In TechniquesGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunity, InnateImmunity, MucosalInfluenza A Virus, H1N1 SubtypeInterleukin-3LungMacrophages, AlveolarMiceMice, TransgenicModels, ImmunologicalOrthomyxoviridae InfectionsTransplantation ChimeraTransplantation, HeterologousConceptsHuman immune responseImmune responseHuman alveolar macrophagesKI miceAlveolar macrophagesFunctional human immune systemHuman mucosal immune responsesGM-CSFHuman innate immune responseMucosal immune responsesPulmonary alveolar proteinosisHuman immune cellsInnate immune responseUnique mouse modelKnock-In MiceHuman immune systemAlveolar macrophage developmentHuman myeloid cellsHuman infectious diseasesCell reconstitutionHumanized miceAlveolar proteinosisImmune cellsMouse GM-CSFVaccine testing