Efficient differentiation and function of human macrophages in humanized CSF-1 mice
Rathinam C, Poueymirou WT, Rojas J, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rongvaux A, Eynon EE, Manz MG, Flavell RA. Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood 2011, 118: 3119-3128. PMID: 21791433, DOI: 10.1182/blood-2010-12-326926.Peer-Reviewed Original ResearchConceptsHuman monocytes/macrophagesMonocytes/macrophagesMice showHumanized mouse modelMyeloid cell biologyBALB/cHuman fetal liverHuman myeloid cellsHumanized micePeripheral bloodPeritoneal cavityMouse modelNewborn miceBone marrowMyeloid cellsHuman cytokinesHuman hematopoietic systemHuman macrophagesMiceValuable experimental modelExperimental modelFetal liverProgenitor cells