Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice
Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG, Flavell RA. Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 13218-13223. PMID: 21788509, PMCID: PMC3156175, DOI: 10.1073/pnas.1109769108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, DifferentiationBone Marrow CellsCell LineageDNA-Binding ProteinsEpitopesHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHumansImmunity, HumoralInterleukin Receptor Common gamma SubunitMiceMice, Inbred BALB CMice, KnockoutMice, TransgenicReceptors, ImmunologicTransgenesConceptsSignal regulatory protein alphaBALB/c backgroundRegulatory protein alphaNSG miceImmune systemC backgroundHuman hematopoietic cellsNOD/SCID/Mouse strainsProtein alphaHuman cell engraftmentBALB/cUnique mouse strainHost immune functionHematopoietic cellsHuman immune systemHumanized miceSCID/Human hematopoietic stem cellsImmune responseHuman engraftmentSimilar miceImmune functionNewborn miceCell engraftmentHuman thrombopoietin knockin mice efficiently support human hematopoiesis in vivo
Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S, Manz MG, Flavell RA. Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 2378-2383. PMID: 21262827, PMCID: PMC3038726, DOI: 10.1073/pnas.1019524108.Peer-Reviewed Original Research