The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer.
Haiman CA, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Speizer FE, Kelsey KT, Hunter DJ. The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer. Cancer Research 1999, 59: 1015-20. PMID: 10070957.Peer-Reviewed Original ResearchConceptsHealth Study cohortBreast cancer riskBreast cancerHormone levelsA2 alleleCancer riskNurses' Health Study cohortStrong independent risk factorA2/A2 genotypeCYP17 A2 alleleElevated levelsAdvanced breast cancerIncident breast cancerIndependent risk factorPolycystic ovarian syndromeCertain steroid hormonesA1/A1 genotypeCase-control studyPlasma hormone levelsSteroid hormone levelsLater agePremenopausal womenCYP17 genotypeHormone replacementOvarian syndrome