2020
Tantrum Tool: Development and Open Pilot Study of Online Parent Training for Irritability and Disruptive Behavior
Diaz-Stransky A, Rowley S, Zecher E, Grodberg D, Sukhodolsky DG. Tantrum Tool: Development and Open Pilot Study of Online Parent Training for Irritability and Disruptive Behavior. Journal Of Child And Adolescent Psychopharmacology 2020, 30: 558-566. PMID: 33035067, PMCID: PMC7699014, DOI: 10.1089/cap.2020.0089.Peer-Reviewed Original ResearchConceptsOpen pilot studyAffective Reactivity IndexOpen trialPilot studyFirst-line treatmentSecondary outcome measuresDisruptive Behavior Rating ScaleYoung childrenDisruptive behaviorSignificant reductionDisruptive behavior disordersClinical effectsParent management training interventionOutcome measuresEffective treatmentTreatment retentionBehavior disorderClinical settingParent management trainingPrimary caregiversMeaningful reductionRating ScaleIrritability scoresLimited service availabilityParent training program
2019
Anxiety in 3- to 7-year-old children with autism spectrum disorder seeking treatment for disruptive behavior
Sukhodolsky DG, Lecavalier L, Johnson C, Smith T, Swiezy N, Bearss K, Kalvin CB, Scahill L. Anxiety in 3- to 7-year-old children with autism spectrum disorder seeking treatment for disruptive behavior. Autism 2019, 24: 400-410. PMID: 31390873, PMCID: PMC6982590, DOI: 10.1177/1362361319866561.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderAnxiety symptomsDisruptive behaviorParent-completed rating scaleOppositional defiant behaviorYoung childrenEarly Childhood InventorySchool-aged childrenAnxiety severity scoresChild psychiatric symptomsParent trainingDefiant behaviorOppositional behaviorBehavioral problemsSocial withdrawalPreschool childrenAnxietyIQSocial disabilityPsychiatric symptomsChildrenRating ScalePercent of childrenSignificant symptomsAltered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality‐Controlled Diffusion Tensor Imaging Study
Lei J, Lecarie E, Jurayj J, Boland S, Sukhodolsky DG, Ventola P, Pelphrey KA, Jou RJ. Altered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality‐Controlled Diffusion Tensor Imaging Study. Autism Research 2019, 12: 1472-1483. PMID: 31347307, PMCID: PMC6851962, DOI: 10.1002/aur.2180.Peer-Reviewed Original Research
2016
Moderators of Parent Training for Disruptive Behaviors in Young Children with Autism Spectrum Disorder
Lecavalier L, Smith T, Johnson C, Bearss K, Swiezy N, Aman MG, Sukhodolsky DG, Deng Y, Dziura J, Scahill L. Moderators of Parent Training for Disruptive Behaviors in Young Children with Autism Spectrum Disorder. Research On Child And Adolescent Psychopathology 2016, 45: 1235-1245. PMID: 27917460, PMCID: PMC5459681, DOI: 10.1007/s10802-016-0233-x.Peer-Reviewed Original ResearchConceptsHome Situations QuestionnaireAutism spectrum disorderParent education programAttention deficit hyperactivity disorderParent trainingAberrant Behavior Checklist-Irritability subscaleSpectrum disorderClinical Global Impressions-Improvement scaleDisruptive behaviorOppositional defiant disorder symptomsASD symptom severityLow anxiety groupDeficit hyperactivity disorderYoung childrenADHD groupASD severityHyperactivity disorderAnxiety groupDisorder symptomsPotential moderatorsSituations QuestionnaireNoncompliant behaviorAge 3ModeratorSymptom severityBrain responses to biological motion predict treatment outcome in young children with autism
Yang D, Pelphrey KA, Sukhodolsky DG, Crowley MJ, Dayan E, Dvornek NC, Venkataraman A, Duncan J, Staib L, Ventola P. Brain responses to biological motion predict treatment outcome in young children with autism. Translational Psychiatry 2016, 6: e948-e948. PMID: 27845779, PMCID: PMC5314125, DOI: 10.1038/tp.2016.213.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderYoung childrenSocial information processingMultivariate pattern analysisMotivation/rewardBiological motionCore deficitComplex neurodevelopmental disorderBrain responsesResponse treatmentSpectrum disorderNeurobiological markersNeural predictorsInformation processingBehavioral interventionsIndividual childrenNeurodevelopmental disordersCurrent findingsNeural circuitsBehavioral deficitsEarly childhoodChildrenUnsuccessful interventionsNeurobiomarkersPattern analysisBrief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment
Ventola PE, Yang D, Abdullahi SM, Paisley CA, Braconnier ML, Sukhodolsky DG. Brief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment. Journal Of Autism And Developmental Disorders 2016, 46: 2813-2820. PMID: 27230762, PMCID: PMC4939123, DOI: 10.1007/s10803-016-2813-6.Peer-Reviewed Original ResearchA Randomized Controlled Trial of an Integrated Brain, Body, and Social Intervention for Children With ADHD
Smith SD, Vitulano LA, Katsovich L, Li S, Moore C, Li F, Grantz H, Zheng X, Eicher V, Guloksuz S, Zheng Y, Dong J, Sukhodolsky DG, Leckman JF. A Randomized Controlled Trial of an Integrated Brain, Body, and Social Intervention for Children With ADHD. Journal Of Attention Disorders 2016, 24: 780-794. PMID: 27178060, PMCID: PMC5107355, DOI: 10.1177/1087054716647490.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityBehavior TherapyBrainChildChild, PreschoolHumansMemory, Short-TermTreatment OutcomeConceptsIntegrated brainComputerized cognitive remediation trainingCognitive remediation trainingSocial interventionsBehavior management strategiesRemediation trainingCognitive trainingMemory taskADHD symptomatologyADHD symptomsNeurocognitive testsTeacher ratingsBlinded clinician ratingGeneralized improvementADHDMultiple group comparisonsClinician ratingsMultiple domainsClinical functioningSignificant treatment effectOutcome measuresGroup comparisonsSecondary outcome measuresChildrenRatingsEffect of Parent Training on Adaptive Behavior in Children With Autism Spectrum Disorder and Disruptive Behavior: Results of a Randomized Trial
Scahill L, Bearss K, Lecavalier L, Smith T, Swiezy N, Aman MG, Sukhodolsky DG, McCracken C, Minshawi N, Turner K, Levato L, Saulnier C, Dziura J, Johnson C. Effect of Parent Training on Adaptive Behavior in Children With Autism Spectrum Disorder and Disruptive Behavior: Results of a Randomized Trial. Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: 602-609.e3. PMID: 27343887, DOI: 10.1016/j.jaac.2016.05.001.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderParent training groupParent trainingDaily living skillsDisruptive behaviorAdaptive behaviorParent educationSpectrum disorderLiving skillsVineland Adaptive Behavior Scales-IIHigh-functioning childrenTraining groupGreater behavioral problemsYoung childrenIntellectual disabilityBehavior management strategiesAdaptive functioningSocialization domainsTelephone boosterBehavioral problemsScale IIDaily livingCommunication domainCore sessionsDaily living domains
2015
Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials
Scahill L, Sukhodolsky DG, Anderberg E, Dimitropoulos A, Dziura J, Aman MG, McCracken J, Tierney E, Hallett V, Katz K, Vitiello B, McDougle C. Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials. Autism 2015, 20: 145-152. PMID: 25882391, DOI: 10.1177/1362361315574889.Peer-Reviewed Original Research
2014
Heterogeneity of neural mechanisms of response to pivotal response treatment
Ventola P, Yang DY, Friedman HE, Oosting D, Wolf J, Sukhodolsky DG, Pelphrey KA. Heterogeneity of neural mechanisms of response to pivotal response treatment. Brain Imaging And Behavior 2014, 9: 74-88. PMID: 25370452, PMCID: PMC4993028, DOI: 10.1007/s11682-014-9331-y.Peer-Reviewed Original ResearchConceptsPivotal Response TreatmentPosterior superior temporal sulcusFunctional magnetic resonance imagingAutism spectrum disorderNeural responsesResponse treatmentRight posterior superior temporal sulcusBiological motion perception taskDifferential neural responsesMotion perception taskSuperior temporal sulcusPerception taskTD childrenTemporal sulcusSocial perceptionBrain responsesNeural mechanismsSpectrum disorderSocial communicationNeural vulnerabilityNeural characteristicsNeural systemsVentral striatumReward systemSubcortical regionsExamination of Aggression and Self-injury in Children with Autism Spectrum Disorders and Serious Behavioral Problems
Carroll D, Hallett V, McDougle CJ, Aman MG, McCracken JT, Tierney E, Arnold LE, Sukhodolsky DG, Lecavalier L, Handen BL, Swiezy N, Johnson C, Bearss K, Vitiello B, Scahill L. Examination of Aggression and Self-injury in Children with Autism Spectrum Disorders and Serious Behavioral Problems. Child And Adolescent Psychiatric Clinics Of North America 2014, 23: 57-72. PMID: 24231167, PMCID: PMC4212264, DOI: 10.1016/j.chc.2013.08.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionAnalysis of VarianceAntipsychotic AgentsChildChild Development Disorders, PervasiveChild, PreschoolChi-Square DistributionDouble-Blind MethodFemaleHumansIntelligence TestsMaleOutcome Assessment, Health CarePsychiatric Status Rating ScalesRandomized Controlled Trials as TopicRisperidoneSelf-Injurious BehaviorSeverity of Illness IndexConceptsAutism spectrum disorderSubtypes of aggressionSelf-injurious behaviorSpectrum disorderUnderstanding of aggressionSerious behavioral problemsParent interviewsBehavioral problemsSelf-InjuryAggressionStudy findingsChildrenRisperidone trialsChildren 2DisordersIndividualized treatmentPositive responseSubtypesFurther studiesBiological mechanismsHigh rateInterviewsFindingsNarrativesBehavior
2013
Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies
Nurmi E, Spilman S, Whelan F, Scahill L, Aman M, McDougle C, Arnold L, Handen B, Johnson C, Sukhodolsky D, Posey D, Lecavalier L, Stigler K, Ritz L, Tierney E, Vitiello B, McCracken J. Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies. Translational Psychiatry 2013, 3: e274-e274. PMID: 23799528, PMCID: PMC3693401, DOI: 10.1038/tp.2013.26.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlpha-Ketoglutarate-Dependent Dioxygenase FTOAmidohydrolasesAntipsychotic AgentsBody WeightChildChild Development Disorders, PervasiveChild, PreschoolFemaleGenetic Predisposition to DiseaseHumansLeptinMaleProteinsReceptor, Cannabinoid, CB1Receptor, Melanocortin, Type 4RisperidoneWeight GainConceptsWeight gainAntipsychotic-associated weight gainAntipsychotic-induced weight gainEndocannabinoid metabolic enzymesPrior adult studiesTreatment-naive populationExcessive weight gainHigh-risk groupFatty acid amide hydrolaseTreatment of irritabilityChildren/adolescentsRisperidone studyAntipsychotic exposureAdverse eventsPlasma levelsRisk groupsAdult studiesCannabinoid receptorsNetwork trialAmide hydrolasePharmacogenetic basisGene variantsSignificant riskTrend associationNaive populationExploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders
Hallett V, Lecavalier L, Sukhodolsky DG, Cipriano N, Aman MG, McCracken JT, McDougle CJ, Tierney E, King BH, Hollander E, Sikich L, Bregman J, Anagnostou E, Donnelly C, Katsovich L, Dukes K, Vitiello B, Gadow K, Scahill L. Exploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders. Journal Of Autism And Developmental Disorders 2013, 43: 2341-2352. PMID: 23400347, PMCID: PMC4038127, DOI: 10.1007/s10803-013-1775-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyChildChild Development Disorders, PervasiveChild, PreschoolFemaleHumansLanguage DevelopmentMaleConceptsLow-functioning childrenAutism spectrum disorderUnderstanding of anxietyManifestations of anxietySocial anxietyBehavioral measuresSeparation anxietySpectrum disorderAnxiety symptomsHigh anxietyGeneralized anxietyAnxiety ScaleSleep difficultiesVerbal expressionAnxietyHigher scoresIQDSM-IVChildrenItemsASDWorryLanguageASDsDisorders
2011
Effects of Risperidone and Parent Training on Adaptive Functioning in Children With Pervasive Developmental Disorders and Serious Behavioral Problems
Scahill L, McDougle CJ, Aman MG, Johnson C, Handen B, Bearss K, Dziura J, Butter E, Swiezy NG, Arnold LE, Stigler KA, Sukhodolsky DD, Lecavalier L, Pozdol SL, Nikolov R, Hollway JA, Korzekwa P, Gavaletz A, Kohn AE, Koenig K, Grinnon S, Mulick JA, Yu S, Vitiello B, Network R. Effects of Risperidone and Parent Training on Adaptive Functioning in Children With Pervasive Developmental Disorders and Serious Behavioral Problems. Journal Of The American Academy Of Child & Adolescent Psychiatry 2011, 51: 136-146. PMID: 22265360, PMCID: PMC3941712, DOI: 10.1016/j.jaac.2011.11.010.Peer-Reviewed Original ResearchAdaptation, PsychologicalAdolescentAntipsychotic AgentsAsperger SyndromeAutistic DisorderChecklistChildChild Behavior DisordersChild Development Disorders, PervasiveChild, PreschoolCombined Modality TherapyCommunicationCooperative BehaviorDose-Response Relationship, DrugEducationFemaleHumansMaleRisperidoneSocialization
2010
The Home Situations Questionnaire‐PDD version: Factor structure and psychometric properties
Chowdhury M, Aman MG, Scahill L, Swiezy N, Arnold LE, Lecavalier L, Johnson C, Handen B, Stigler K, Bearss K, Sukhodolsky D, McDougle CJ. The Home Situations Questionnaire‐PDD version: Factor structure and psychometric properties. Journal Of Intellectual Disability Research 2010, 54: 281-291. PMID: 20377705, DOI: 10.1111/j.1365-2788.2010.01259.x.Peer-Reviewed Original Research
2009
Medication and Parent Training in Children With Pervasive Developmental Disorders and Serious Behavior Problems: Results From a Randomized Clinical Trial
Aman MG, Mcdougle CJ, Scahill L, Handen B, Arnold LE, Johnson C, Stigler KA, Bearss K, Butter E, Swiezy NB, Sukhodolsky DD, Ramadan Y, Pozdol SL, Nikolov R, Lecavalier L, Kohn AE, Koenig K, Hollway JA, Korzekwa P, Gavaletz A, Mulick JA, Hall KL, Dziura J, Ritz L, Trollinger S, Yu S, Vitiello B, Wagner A, Network F. Medication and Parent Training in Children With Pervasive Developmental Disorders and Serious Behavior Problems: Results From a Randomized Clinical Trial. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 1143-1154. PMID: 19858761, PMCID: PMC3142923, DOI: 10.1097/chi.0b013e3181bfd669.Peer-Reviewed Original ResearchConceptsPervasive developmental disorderClinical trialsClinical Global Impressions-Improvement scoreAberrant Behavior Checklist IrritabilityParallel-group clinical trialParent trainingBehavioral problemsDevelopmental disordersRisperidone doseRisperidone monotherapyHyperactivity/noncompliance subscaleSevere behavioral problemsCOMB groupPT sessionsQuestionnaire scoresHSQ scoresMedicationsGreater reductionChildrenPrimary measureRisperidoneSignificant reductionStereotypic behaviorScoresDoseStandardised Observation Analogue Procedure (SOAP) for assessing parent and child behaviours in clinical trials
Johnson CR, Butter EM, Handen BL, Sukhodolsky DG, Mulick J, Lecavalier L, Aman MG, Arnold E, Scahill L, Swiezy N, Sacco K, Stigler KA, McDougle CJ. Standardised Observation Analogue Procedure (SOAP) for assessing parent and child behaviours in clinical trials. Journal Of Intellectual & Developmental Disability 2009, 34: 230-238. PMID: 19681003, PMCID: PMC2739602, DOI: 10.1080/13668250903074471.Peer-Reviewed Original ResearchConceptsPervasive developmental disorderInappropriate child behaviorChild behaviorParent ratingsStructured parent training programParent-child behaviorsPsychological intervention researchParent training programAnalog procedureField of autismMedium effect sizeObservations of behaviorChild noncomplianceObservational measuresDevelopmental disabilitiesIntervention researchDevelopmental disordersValid measureNoncompliant behaviorTraining programEffect sizeModerate positive correlationBaseline scoresInter-rater reliabilityChildren
2007
Parent-Rated Anxiety Symptoms in Children with Pervasive Developmental Disorders: Frequency and Association with Core Autism Symptoms and Cognitive Functioning
Sukhodolsky DG, Scahill L, Gadow KD, Arnold LE, Aman MG, McDougle CJ, McCracken JT, Tierney E, Williams White S, Lecavalier L, Vitiello B. Parent-Rated Anxiety Symptoms in Children with Pervasive Developmental Disorders: Frequency and Association with Core Autism Symptoms and Cognitive Functioning. Research On Child And Adolescent Psychopathology 2007, 36: 117-128. PMID: 17674186, DOI: 10.1007/s10802-007-9165-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionAntipsychotic AgentsAnxietyAsperger SyndromeAttention Deficit Disorder with HyperactivityAutistic DisorderCentral Nervous System StimulantsChildChild Development Disorders, PervasiveChild, PreschoolCognition DisordersComorbidityCross-Over StudiesDouble-Blind MethodFemaleHumansIntelligenceLanguage Development DisordersMaleMethylphenidatePersonality AssessmentRandomized Controlled Trials as TopicRisperidoneSocial BehaviorStereotyped BehaviorConceptsPervasive developmental disorderParent-rated anxiety symptomsAnxiety symptomsHigher IQCore symptomsDevelopmental disordersCore autism symptomsAdolescent Symptom InventoryFunctional language useMedication-free childrenSocial anxietyAutism symptomsCognitive functioningParent ratingsSocial reciprocityResultsForty-three percentProblem behaviorAnxiety disordersSymptom InventoryOverall impairmentAnxietyGreater impairmentLanguage useStereotyped behaviorIQ
2004
The Impact of Managed Care on Children's Outpatient Treatment: A Comparison Study of Treatment Outcome Before and After Managed Care
Armbruster P, Sukhodolsky D, Michalsen R. The Impact of Managed Care on Children's Outpatient Treatment: A Comparison Study of Treatment Outcome Before and After Managed Care. American Journal Of Orthopsychiatry 2004, 74: 5-13. PMID: 14769104, DOI: 10.1037/0002-9432.74.1.5.Peer-Reviewed Original Research
1995
Anger Disorders: Basic Science and Practice Issues
Kassinove H, Sukhodolsky D. Anger Disorders: Basic Science and Practice Issues. Comprehensive Child And Adolescent Nursing 1995, 18: 173-205. PMID: 8707651, DOI: 10.3109/01460869509087270.Peer-Reviewed Original Research