2024
Review: Evidence-Based Psychosocial Treatments for Childhood Irritability and Aggressive Behavior
Kalvin C, Zhong J, Rutten M, Ibrahim K, Sukhodolsky D. Review: Evidence-Based Psychosocial Treatments for Childhood Irritability and Aggressive Behavior. JAACAP Open 2024 DOI: 10.1016/j.jaacop.2024.01.009.Peer-Reviewed Original ResearchCognitive-behavioral therapyParent management trainingDialectical behavior therapyChildhood irritabilityChildhood aggressionMaladaptive aggressionPsychosocial treatmentsPsychosocial interventionsReview of evidence-based psychosocial treatmentsDisruptive mood dysregulation disorderEvidence-based psychosocial treatmentsCo-occurring psychopathologySevere mood dysregulationOutpatient mental health servicesChild psychiatric disordersChild mental healthMental health servicesMood dysregulationBehavioral therapyDysregulation disorderPsychiatric disordersDisruptive behaviorWell-powered randomized controlled trialsAggressive behaviorRelevant to clinical practice
2020
Sex differences in medial prefrontal and parietal cortex structure in children with disruptive behavior
Ibrahim K, Kalvin C, Li F, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Sex differences in medial prefrontal and parietal cortex structure in children with disruptive behavior. Developmental Cognitive Neuroscience 2020, 47: 100884. PMID: 33254067, PMCID: PMC7704291, DOI: 10.1016/j.dcn.2020.100884.Peer-Reviewed Original ResearchConceptsDisruptive behavior disordersGray matter volumeCortical thicknessMatter volumeSex differencesDisruptive behavior severityCross-sectional studySex-specific associationsDisruptive behaviorLeft ventromedial prefrontal cortexWhole-brain analysisSurface-based morphometryStructural MRI dataHealthy controlsSex-specific differencesNeural biomarkersTarget-based treatmentVentromedial prefrontal cortexMedial prefrontalBehavior disorderPrefrontal cortexBrain structuresSupramarginal gyrusRespective controlsVmPFC volumeTantrum Tool: Development and Open Pilot Study of Online Parent Training for Irritability and Disruptive Behavior
Diaz-Stransky A, Rowley S, Zecher E, Grodberg D, Sukhodolsky DG. Tantrum Tool: Development and Open Pilot Study of Online Parent Training for Irritability and Disruptive Behavior. Journal Of Child And Adolescent Psychopharmacology 2020, 30: 558-566. PMID: 33035067, PMCID: PMC7699014, DOI: 10.1089/cap.2020.0089.Peer-Reviewed Original ResearchConceptsOpen pilot studyAffective Reactivity IndexOpen trialPilot studyFirst-line treatmentSecondary outcome measuresDisruptive Behavior Rating ScaleYoung childrenDisruptive behaviorSignificant reductionDisruptive behavior disordersClinical effectsParent management training interventionOutcome measuresEffective treatmentTreatment retentionBehavior disorderClinical settingParent management trainingPrimary caregiversMeaningful reductionRating ScaleIrritability scoresLimited service availabilityParent training program
2019
Anxiety in 3- to 7-year-old children with autism spectrum disorder seeking treatment for disruptive behavior
Sukhodolsky DG, Lecavalier L, Johnson C, Smith T, Swiezy N, Bearss K, Kalvin CB, Scahill L. Anxiety in 3- to 7-year-old children with autism spectrum disorder seeking treatment for disruptive behavior. Autism 2019, 24: 400-410. PMID: 31390873, PMCID: PMC6982590, DOI: 10.1177/1362361319866561.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderAnxiety symptomsDisruptive behaviorParent-completed rating scaleOppositional defiant behaviorYoung childrenEarly Childhood InventorySchool-aged childrenAnxiety severity scoresChild psychiatric symptomsParent trainingDefiant behaviorOppositional behaviorBehavioral problemsSocial withdrawalPreschool childrenAnxietyIQSocial disabilityPsychiatric symptomsChildrenRating ScalePercent of childrenSignificant symptomsReduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior
Ibrahim K, Eilbott JA, Ventola P, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Reduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 4: 1031-1041. PMID: 30979647, PMCID: PMC7173634, DOI: 10.1016/j.bpsc.2019.01.009.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCallous-unemotional traitsAmygdala-vlPFC connectivityDisruptive behaviorAmygdala reactivityNeural mechanismsSpectrum disorderAmygdala-prefrontal functional connectivityEmotion perception taskFunctional magnetic resonance imagingVentrolateral prefrontal cortexUnderlying neural mechanismsDisruptive behavior disordersTask-specific changesRisk of aggressionEmotion dysregulationFearful facesCalm facesPerception taskFear processingAmygdala activityPsychophysiological interactionAmygdala connectivityExternalizing behaviorsAmygdala hyperactivity
2018
Cognitive Behavioral Therapy for Anger and Aggression in a Child With Tourette’s Syndrome
Tudor M, Bertschinger E, Piasecka J, Sukhodolsky D. Cognitive Behavioral Therapy for Anger and Aggression in a Child With Tourette’s Syndrome. Clinical Case Studies 2018, 17: 220-232. DOI: 10.1177/1534650118782438.ChaptersTourette syndromeOppositional defiant disorderAnger outburstsPrimary clinical concernContext of TSBehavioral therapy treatmentCognitive behavioral therapy treatmentCognitive behavioral therapySelect supplementsUseful treatmentMotor ticsDisruptive behaviorClinical concernPosttreatment assessmentBehavioral therapyWeekly sessionsAnxiety disordersTherapy treatmentSyndromeNeurodevelopmental disordersSignificant decreaseDefiant disorderInitial assessmentDisordersAggressive behavior
2017
Reduced anxiety following pivotal response treatment in young children with autism spectrum disorder
Lei J, Sukhodolsky DG, Abdullahi SM, Braconnier ML, Ventola P. Reduced anxiety following pivotal response treatment in young children with autism spectrum disorder. Research In Autism Spectrum Disorders 2017, 43: 1-7. PMID: 29333196, PMCID: PMC5761743, DOI: 10.1016/j.rasd.2017.09.002.Peer-Reviewed Original ResearchPivotal Response TreatmentResponse treatmentAnxiety symptomsAnxiety reductionYoung childrenCo-occurring anxiety symptomsAttention deficit hyperactivity disorderSocial communication skillsAutism symptom severityAdolescent Symptom InventoryAutism spectrum disorderCognitive behavioral therapySignificant anxiety reductionCo-occurring symptomsApplied behavior analysisSchool-aged childrenHyperactivity disorderBehavioral therapySpectrum disorderBehavioral treatmentDisruptive behaviorReduced anxietyAnxiety subscaleSymptom InventoryASDDistinct neural bases of disruptive behavior and autism symptom severity in boys with autism spectrum disorder
Yang YJ, Sukhodolsky DG, Lei J, Dayan E, Pelphrey KA, Ventola P. Distinct neural bases of disruptive behavior and autism symptom severity in boys with autism spectrum disorder. Journal Of Neurodevelopmental Disorders 2017, 9: 1. PMID: 28115995, PMCID: PMC5240249, DOI: 10.1186/s11689-017-9183-z.Peer-Reviewed Original ResearchAutism spectrum disorderAutism symptom severityMedial prefrontal cortexAnterior cingulate cortexLow disruptive behaviorCore ASD symptomsBiological motionNeural basisDMN deactivationDisruptive behaviorADHD symptomsASD symptomsSpectrum disorderAnxiety symptomsSymptom severityPosterior superior temporal sulcusBetween-group analysisDefault mode network deactivationDistinct neural basesSuperior temporal sulcusInferior frontal gyrusHigh disruptive behaviorLateral parietal cortexASD participantsNeural underpinnings
2016
Moderators of Parent Training for Disruptive Behaviors in Young Children with Autism Spectrum Disorder
Lecavalier L, Smith T, Johnson C, Bearss K, Swiezy N, Aman MG, Sukhodolsky DG, Deng Y, Dziura J, Scahill L. Moderators of Parent Training for Disruptive Behaviors in Young Children with Autism Spectrum Disorder. Research On Child And Adolescent Psychopathology 2016, 45: 1235-1245. PMID: 27917460, PMCID: PMC5459681, DOI: 10.1007/s10802-016-0233-x.Peer-Reviewed Original ResearchConceptsHome Situations QuestionnaireAutism spectrum disorderParent education programAttention deficit hyperactivity disorderParent trainingAberrant Behavior Checklist-Irritability subscaleSpectrum disorderClinical Global Impressions-Improvement scaleDisruptive behaviorOppositional defiant disorder symptomsASD symptom severityLow anxiety groupDeficit hyperactivity disorderYoung childrenADHD groupASD severityHyperactivity disorderAnxiety groupDisorder symptomsPotential moderatorsSituations QuestionnaireNoncompliant behaviorAge 3ModeratorSymptom severityEffect of Parent Training on Adaptive Behavior in Children With Autism Spectrum Disorder and Disruptive Behavior: Results of a Randomized Trial
Scahill L, Bearss K, Lecavalier L, Smith T, Swiezy N, Aman MG, Sukhodolsky DG, McCracken C, Minshawi N, Turner K, Levato L, Saulnier C, Dziura J, Johnson C. Effect of Parent Training on Adaptive Behavior in Children With Autism Spectrum Disorder and Disruptive Behavior: Results of a Randomized Trial. Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: 602-609.e3. PMID: 27343887, DOI: 10.1016/j.jaac.2016.05.001.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderParent training groupParent trainingDaily living skillsDisruptive behaviorAdaptive behaviorParent educationSpectrum disorderLiving skillsVineland Adaptive Behavior Scales-IIHigh-functioning childrenTraining groupGreater behavioral problemsYoung childrenIntellectual disabilityBehavior management strategiesAdaptive functioningSocialization domainsTelephone boosterBehavioral problemsScale IIDaily livingCommunication domainCore sessionsDaily living domainsBehavioral Interventions for Anger, Irritability, and Aggression in Children and Adolescents
Sukhodolsky DG, Smith SD, McCauley SA, Ibrahim K, Piasecka JB. Behavioral Interventions for Anger, Irritability, and Aggression in Children and Adolescents. Journal Of Child And Adolescent Psychopharmacology 2016, 26: 58-64. PMID: 26745682, PMCID: PMC4808268, DOI: 10.1089/cap.2015.0120.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyParent management trainingAnger/irritabilityTransdiagnostic approachBehavioral interventionsDisruptive behaviorAggressive behaviorChild disruptive behaviorCallous-unemotional traitsDisruptive behavior disordersTreatment of irritabilityEmotion regulationAversive patternFamily interactionsBehavioral problemsAngerMental health referralsAggressionManagement trainingBehavior disorderMood disordersTreatment targetsIrritabilityChildrenPsychiatric diagnosis
2015
Effect of Parent Training vs Parent Education on Behavioral Problems in Children With Autism Spectrum Disorder: A Randomized Clinical Trial
Bearss K, Johnson C, Smith T, Lecavalier L, Swiezy N, Aman M, McAdam DB, Butter E, Stillitano C, Minshawi N, Sukhodolsky DG, Mruzek DW, Turner K, Neal T, Hallett V, Mulick JA, Green B, Handen B, Deng Y, Dziura J, Scahill L. Effect of Parent Training vs Parent Education on Behavioral Problems in Children With Autism Spectrum Disorder: A Randomized Clinical Trial. JAMA 2015, 313: 1524-1533. PMID: 25898050, PMCID: PMC9078140, DOI: 10.1001/jama.2015.3150.Peer-Reviewed Original ResearchConceptsAberrant Behavior Checklist-Irritability subscaleClinical Global Impressions-Improvement scaleParent trainingCo-primary outcomesAutism spectrum disorderClinical Global ImpressionSpectrum disorderDisruptive behaviorParent-reported outcomesParent educationPositive responseClinical improvementSecondary outcomesWeek 24Global ImpressionBlinded cliniciansClinical trialsClinical significanceMAIN OUTCOMEImprovement ScaleGreater severityTreatment assignment
2014
Clinical Correlates and Predictors of Caregiver Strain in Children With Chronic Tic Disorders
Ramanujam K, Himle MB, Hayes LP, Woods DW, Scahill L, Sukhodolsky DG, Wilhelm S, Deckersbach T, Peterson AL, Specht M, Walkup JT, Chang S, Piacentini J. Clinical Correlates and Predictors of Caregiver Strain in Children With Chronic Tic Disorders. Children's Health Care 2014, 44: 249-263. PMID: 26855465, PMCID: PMC4739807, DOI: 10.1080/02739615.2014.948166.Peer-Reviewed Original ResearchChronic tic disorderCaregiver strainClinical correlatesInattention/hyperactivityTic disordersRandomized-controlled trialTic intensityParents of childrenCare providersBehavior therapyComorbid internalizingExternalizing problemsDisruptive behaviorChildrenObjective strainHyperactivityPredictorsDisordersCurrent studyBest predictorCorrelatesTherapyImpairmentTrials
2013
Toward an exportable parent training program for disruptive behaviors in autism spectrum disorder
Bearss K, Lecavalier L, Minshawi N, Johnson C, Smith T, Handen B, Sukhodolsky D, Aman M, Swiezy N, Butter E, Scahill L. Toward an exportable parent training program for disruptive behaviors in autism spectrum disorder. Neuropsychiatry 2013, 3: 169-180. PMID: 23772233, PMCID: PMC3678377, DOI: 10.2217/npy.13.14.Peer-Reviewed Original ResearchAutism spectrum disorderSpectrum disorderDisruptive behaviorParent training programDisruptive behavior problemsPrevalence of ASDTreatment development modelCases of ASDTherapist trainingRepetitive behaviorsBehavior problemsTreatment manualSocial interactionTreatment integrityProfound deficitsImpaired communicationTraining programEmpirical foundationPediatric psychopharmacologyEarly childhood onsetTreatment acceptanceChildrenPT programEvidence baseManual developmentExposure and response prevention with or without parent management training for children with obsessive-compulsive disorder complicated by disruptive behavior: A multiple-baseline across-responses design study
Sukhodolsky DG, Gorman BS, Scahill L, Findley D, McGuire J. Exposure and response prevention with or without parent management training for children with obsessive-compulsive disorder complicated by disruptive behavior: A multiple-baseline across-responses design study. Journal Of Anxiety Disorders 2013, 27: 298-305. PMID: 23602943, DOI: 10.1016/j.janxdis.2013.01.005.Peer-Reviewed Original ResearchConceptsChildren's Yale-Brown Obsessive Compulsive ScaleParent management trainingWeekly sessionsResponse preventionWeek waiting periodYale-Brown Obsessive Compulsive ScaleDisruptive behaviorExposure-based cognitive-behavioral treatmentDisruptive behavior disordersCY-BOCS scoresObsessive Compulsive ScaleObsessive-compulsive disorderCognitive-behavioral treatmentPercent reductionWeekly ratingsOutcome assessmentExperienced cliniciansBehavior disorderTreatment assignmentBehavioral treatmentCompulsive ScaleSingle-subject studyWaiting periodExposure activitiesChildren
2009
Randomized Trial of Anger Control Training for Adolescents With Tourette's Syndrome and Disruptive Behavior
Sukhodolsky DG, Vitulano LA, Carroll DH, McGuire J, Leckman JF, Scahill L. Randomized Trial of Anger Control Training for Adolescents With Tourette's Syndrome and Disruptive Behavior. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 413-421. PMID: 19242384, DOI: 10.1097/chi.0b013e3181985050.Peer-Reviewed Original ResearchConceptsClinical Global Impressions-Improvement scaleTourette syndromeACT groupControl trainingTAU control groupPrimary outcome measureIndependent evaluatorsAnger control trainingRating Scale scoresDisruptive behaviorEnd point evaluationLarge trialsBehavior rating scale scoresRandomized subjectsTAU conditionOutcome measuresScale scoreControl groupSyndromeRating ScaleACT conditionBehavior Rating ScaleAdolescentsTrialsDisruptive Behavior Rating Scale
2006
Randomized Trial of Parent Management Training in Children With Tic Disorders and Disruptive Behavior
Scahill L, Sukhodolsky DG, Bearss K, Findley D, Hamrin V, Carroll DH, Rains AL. Randomized Trial of Parent Management Training in Children With Tic Disorders and Disruptive Behavior. Journal Of Child Neurology 2006, 21: 650-656. PMID: 16970865, DOI: 10.1177/08830738060210080201.Peer-Reviewed Original ResearchConceptsTic disordersParent management trainingUsual groupClinical Global ImpressionShort-term efficacyRating Scale scoresShort-term improvementDisruptive behaviorRandomized trialsStable medicationBehavior rating scale scoresGlobal ImpressionParent management training programsClinical trialsImprovement ScaleScale scoreStructured parent training programTraining programTreatment assignmentParent training programTraining groupDisruptive behavior problemsDisordersClinical samplesSevere levels
2005
The role of the school psychologist in the inclusive education of school-age children with autism spectrum disorders
Williams S, Johnson C, Sukhodolsky D. The role of the school psychologist in the inclusive education of school-age children with autism spectrum disorders. Journal Of School Psychology 2005, 43: 117-136. DOI: 10.1016/j.jsp.2005.01.002.Peer-Reviewed Original ResearchSchool psychologistsInclusive educationAutism spectrum disorderInclusion of studentsRegular education classroomsEducation of studentsEducation classroomsEvidence-based practiceAvailable intervention techniquesEducational programmingSpecial needsSchool-aged childrenStudentsEducationDisruptive behaviorSpectrum disorderSocial integrationPsychologistsClassroomIntervention techniquesLearningEmpirical supportChildrenNeedIndependent trendsPublic health significance of tic disorders in children and adolescents.
Scahill L, Sukhodolsky DG, Williams SK, Leckman JF. Public health significance of tic disorders in children and adolescents. Advances In Neurology 2005, 96: 240-8. PMID: 16383223.Peer-Reviewed Original ResearchConceptsTic disordersPresence of ADHDAbsence of ADHDPublic health significanceCommunity sampleMild ticsPersistent ticsGreater disabilityVocal ticsDaily livingDisruptive behaviorChronic ticsHealth significanceDisordersClinical samplesCommunity surveyChildrenADHDMinimal consequencesMultiple motorsImpairmentDismantling anger control training for children: A randomized pilot study of social problem-solving versus social skills training components
Sukhodolsky D, Golub A, Stone E, Orban L. Dismantling anger control training for children: A randomized pilot study of social problem-solving versus social skills training components. Behavior Therapy 2005, 36: 15-23. DOI: 10.1016/s0005-7894(05)80050-4.Peer-Reviewed Original ResearchAnger control trainingConduct problemsControl trainingSocial problem-solving trainingSocial cognitive deficitsHostile attribution biasSocial skills trainingProblem-solving trainingMeasures of aggressionCognitive restructuringAttribution biasBehavioral rehearsalSocial skillsParent ratingsInterpersonal conflictTreatment gainsSocial competenciesTreatment completersExcessive angerAttribution retrainingSkills trainingAnger controlAnger expressionDisruptive behaviorCompetent responses