2018
Engineered Animal Models Designed for Investigating Ethanol Metabolism, Toxicity and Cancer
Marshall S, Chen Y, Singh S, Berrios-Carcamo P, Heit C, Apostolopoulos N, Golla JP, Thompson DC, Vasiliou V. Engineered Animal Models Designed for Investigating Ethanol Metabolism, Toxicity and Cancer. Advances In Experimental Medicine And Biology 2018, 1032: 203-221. PMID: 30362100, PMCID: PMC6743736, DOI: 10.1007/978-3-319-98788-0_14.ChaptersConceptsExact molecular mechanismsMouse modelCellular proteinsEthanol-induced tissue injuryEthanol metabolismEngineered Animal ModelsMolecular mechanismsAldehyde dehydrogenasesLong-term alcohol abuseAlcohol-induced diseasesFurther tissue damageAntioxidant glutathioneImportant mouse modelsCurrent understandingLeading causeTissue injuryIntracellular generationAlcohol abuseAlcohol consumptionAnimal modelsPathogenic eventsPathophysiological consequencesTissue damageMetabolismDNA adducts
2016
Roles of defective ALDH2 polymorphism on liver protection and cancer development
Matsumoto A, Thompson DC, Chen Y, Kitagawa K, Vasiliou V. Roles of defective ALDH2 polymorphism on liver protection and cancer development. Environmental Health And Preventive Medicine 2016, 21: 395-402. PMID: 27714678, PMCID: PMC5112207, DOI: 10.1007/s12199-016-0579-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSerum transaminasesLiver protectionSerum alanine aminotransferase levelsExcessive drinkingAlanine aminotransferase levelsAlcohol-related cancersUseful biological markerAldehyde dehydrogenase 2 geneAminotransferase levelsLiver injuryAlcohol intakeAlcohol dosePotential cancer riskCancer riskALDH2 polymorphismEthanol loadHealthy individualsBiological markersCancer developmentMultiple studiesFurther studiesALDH2TransaminaseDrinkingRisk
2015
Update of the human and mouse Fanconi anemia genes
Dong H, Nebert DW, Bruford EA, Thompson DC, Joenje H, Vasiliou V. Update of the human and mouse Fanconi anemia genes. Human Genomics 2015, 9: 32. PMID: 26596371, PMCID: PMC4657327, DOI: 10.1186/s40246-015-0054-y.Peer-Reviewed Original ResearchConceptsHUGO Gene Nomenclature CommitteeDNA repair pathwaysFanconi anemiaFanconi anemia (FA) complementation group proteinsRepair pathwaysFA DNA repair pathwayCommon DNA repair pathwaySet of genesFanconi anemia genesGene Nomenclature CommitteeNumber of genesFANC genesFA pathogenesisGenomic integrityEvolutionary phylogenyGroup proteinsMutant proteinsMouse orthologRoot symbolFA pathwayPhysiological functionsGenesBone marrow failureGenetic diseasesEvolutionary perspective
2014
Transgenic Mouse Models for Alcohol Metabolism, Toxicity, and Cancer
Heit C, Dong H, Chen Y, Shah YM, Thompson DC, Vasiliou V. Transgenic Mouse Models for Alcohol Metabolism, Toxicity, and Cancer. Advances In Experimental Medicine And Biology 2014, 815: 375-387. PMID: 25427919, PMCID: PMC4323349, DOI: 10.1007/978-3-319-09614-8_22.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsReactive oxygen speciesAldehyde dehydrogenasesCritical biological functionsAlcohol dehydrogenaseFormation of proteinHuman genesBiological functionsMolecular mechanismsVariety of cancersPrimary enzymeGenetic defectsOxygen speciesEnzymeNitrogen speciesEthanol metabolismTransgenic mouse modelOxidative stressSpeciesCytochrome P450Pathogenic eventsMetabolismGenetic polymorphismsAntioxidant mechanismsAlcohol-induced toxicityAlcohol-metabolizing enzymes