2005
Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines
Dwyer-Nield L, Srebernak M, Barrett B, Ahn J, Cosper P, Meyer A, Kisley L, Bauer A, Thompson D, Malkinson A. Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines. Carcinogenesis 2005, 26: 1196-1206. PMID: 15746162, DOI: 10.1093/carcin/bgi061.Peer-Reviewed Original ResearchConceptsMouse lung epithelial cell lineLung epithelial cell lineInducible NO synthaseBiosynthetic enzymesEpithelial cell lineCell linesProstaglandin E2Lung tumor-derived cell linesTumor-derived cell linesNon-tumorigenic linesNitric oxidePG biosynthetic enzymesCytokine exposureInhibition of iNOSNormal lung cellsCyclooxygenase-2 activityPhysiological relevanceLung tumor formationLung tumor growthMouse lung tumorsSpontaneous transformantsTumor formationCritical mediatorControl lungsEpithelial cells
2002
Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis.
Kisley L, Barrett B, Bauer A, Dwyer-Nield L, Barthel B, Meyer A, Thompson D, Malkinson A. Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. Cancer Research 2002, 62: 6850-6. PMID: 12460898.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButylated HydroxytolueneCarcinogensEndothelial Growth FactorsImmunohistochemistryIntercellular Signaling Peptides and ProteinsLungLung NeoplasmsLymphokinesMacrophages, AlveolarMaleMiceMice, KnockoutNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIUrethaneVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsLung tumor multiplicityLung tumorigenesisLung tumorsMouse lung tumorigenesisINOS deficiencyINOS (-/-) miceNitric oxideLung inflammationTumor multiplicityLung cancer chemopreventive agentNitric oxide synthase contentInducible nitric oxide synthaseInducible nitric oxide synthase (iNOS) contentMurine lung tumorigenesisVascular endothelial growth factor (VEGF) expressionChronic lung inflammationRole of iNOSLung cancer patientsWhole lung extractsCOX-2 contentAlveolar macrophage infiltrationNitric oxide synthaseWild-type miceBronchiolar Clara cellsMouse lung tumors
1998
Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines
Thompson D, Porter S, Bauer A, Das K, Ou B, Dwyer-Nield L, White C, Malkinson A. Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines. American Journal Of Physiology 1998, 274: l922-l932. PMID: 9609731, DOI: 10.1152/ajplung.1998.274.6.l922.Peer-Reviewed Original ResearchConceptsLung epithelial cell lineEpithelial cell lineLung epithelial cellsNontumorigenic cellsCell linesMurine lung epithelial cell lineEpithelial cellsMurine lung epithelial cellsTumorigenic counterpartsMRNA stabilityE10 cellsTumorigenic cellsWestern blot analysisProtein synthesisNormal progenitor cellsCell's abilityINOS regulationNuclear factor-kappaB activationProgenitor cellsCytokine-induced NO synthesisSpontaneous transformantsBlot analysisInducible NO synthaseMurine linesTransformation alters
1994
Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries.
Altiere R, Travis D, Roberts J, Thompson D. Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries. Journal Of Pharmacology And Experimental Therapeutics 1994, 270: 269-76. PMID: 8035325.Peer-Reviewed Original ResearchConceptsRelaxant responsesPA2 valuesContractile responsePulmonary arteryMuscarinic receptorsM1-selective antagonist pirenzepineEndothelium-dependent contractionsRabbit intrapulmonary arteriesEndothelium-dependent relaxationIsolated pulmonary arteriesM3-selective antagonistRabbit pulmonary arteryAcetylcholine-induced contractionsMuscarinic receptor subtypesN-methylpiperidine methiodideM2-selective antagonistSubtype-selective antagonistsNitric oxide synthaseInhibitor of cyclooxygenaseElevated toneAntagonist pirenzepineIntrapulmonary arteriesOxide synthaseReceptor subtypesPharmacological characterization