Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries.
Altiere R, Travis D, Roberts J, Thompson D. Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries. Journal Of Pharmacology And Experimental Therapeutics 1994, 270: 269-76. PMID: 8035325.Peer-Reviewed Original ResearchConceptsRelaxant responsesPA2 valuesContractile responsePulmonary arteryMuscarinic receptorsM1-selective antagonist pirenzepineEndothelium-dependent contractionsRabbit intrapulmonary arteriesEndothelium-dependent relaxationIsolated pulmonary arteriesM3-selective antagonistRabbit pulmonary arteryAcetylcholine-induced contractionsMuscarinic receptor subtypesN-methylpiperidine methiodideM2-selective antagonistSubtype-selective antagonistsNitric oxide synthaseInhibitor of cyclooxygenaseElevated toneAntagonist pirenzepineIntrapulmonary arteriesOxide synthaseReceptor subtypesPharmacological characterization